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DR5000
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. NHEJ, in contrast, is a prominent pathway in animal cells but is error prone in nature. A…
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DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. NHEJ, in contrast, is a prominent pathway in animal cells but is error prone in nature. A specific reporter based assay for NHEJ […]
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DR5001-HNHeLa-Sce
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  NHEJ is the major repair pathway in all animal cells and operates continuously during the entire…
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DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  NHEJ is the major repair pathway in all animal cells and operates continuously during the entire cell cycle.  NHEJ is both error prone […]
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DR3000-HRHeLa-Sce
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR…
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DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR can be very beneficial for anti-cancer […]
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DR3050
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication…
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DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase.  […]
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DR5000-HNSH-Sce
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  NHEJ is the major repair pathway in all animal cells and operates continuously during the entire…
Show more (+)
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  NHEJ is the major repair pathway in all animal cells and operates continuously during the entire cell cycle.  NHEJ is both error prone […]
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DR3000-HRHeLa
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication…
Show more (+)
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase.  […]
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DR5000-HN3T3-Sce
TopoGEN scientists have created a novel, cell based kit to follow NHEJ by simply assaying for the presence of GFP positive cells (Fig. 1). A specific reporter based assay for NHEJ can be very beneficial for anti-cancer drug discovery projects, learning more about the process of NHEJ repair and establishing…
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TopoGEN scientists have created a novel, cell based kit to follow NHEJ by simply assaying for the presence of GFP positive cells (Fig. 1). A specific reporter based assay for NHEJ can be very beneficial for anti-cancer drug discovery projects, learning more about the process of NHEJ repair and establishing intersecting pathways and druggable pathway […]
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DR3000-HRSH-Sce
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR…
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DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR can be very beneficial for drug […]
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DR5000-HNCN1.4
TopoGEN scientists have created a novel, cell based kit to follow NHEJ by simply assaying for the presence of GFP positive cells (Fig 1). DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  Homologous recombination (HR) is a minor pathway but very…
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TopoGEN scientists have created a novel, cell based kit to follow NHEJ by simply assaying for the presence of GFP positive cells (Fig 1). DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  Homologous recombination (HR) is a minor pathway but very important in protecting cells from genotoxicity.  […]
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DR3000-HR3T3-Sce
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication…
Show more (+)
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase.  […]
Show less (-)
DR3000
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication…
Show more (+)
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase.  […]
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DR3000-HRCN1.4-Sce
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR…
Show more (+)
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR can be very beneficial for drug […]
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TG2000G
Highly purified DNA Gyrase is offered as a holoenzyme (contains both A,B subunits). This is an excellent reagent for supercoiling plasmids in vitro or for novel drug screens.
TG2000GSA
Highly purified S. aureus DNA gyrase is a type II topoisomerase encoded by two genes GyrA and GyrB from staphylococcus aureus.  DNA gyrase is an essential topoisomerase that supercoils DNA through a process of strand breakage/resealing and DNA wrapping (3).  As a type II enzyme, gyrase is unique…
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Highly purified S. aureus DNA gyrase is a type II topoisomerase encoded by two genes GyrA and GyrB from staphylococcus aureus.  DNA gyrase is an essential topoisomerase that supercoils DNA through a process of strand breakage/resealing and DNA wrapping (3).  As a type II enzyme, gyrase is unique in its ability to negatively supercoil a […]
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TG1019
Topo II inhibitors have been shown to possess effective antibacterial, antiviral and anticancer activity. Identification of topo II inhibitors and antagonists requires tractable biochemical assays employing purified enzyme.  The Topoisomerase II Drug Screening Kit contains the reagents necessary to screen for agents that affect enzymatic activity.  To allow…
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Topo II inhibitors have been shown to possess effective antibacterial, antiviral and anticancer activity. Identification of topo II inhibitors and antagonists requires tractable biochemical assays employing purified enzyme.  The Topoisomerase II Drug Screening Kit contains the reagents necessary to screen for agents that affect enzymatic activity.  To allow the customer maximum flexibility, some kits include […]
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TG1018
The Topo I Drug Kit introduces transient nicks in DNA at specific sites.  Detection of these transient DNA nicks requires trapping the enzyme on DNA in a nicked intermediate complex using protein denaturants. The resulting covalent DNA/topo I complexes contain nicked open circular DNA which can be detected by…
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The Topo I Drug Kit introduces transient nicks in DNA at specific sites.  Detection of these transient DNA nicks requires trapping the enzyme on DNA in a nicked intermediate complex using protein denaturants. The resulting covalent DNA/topo I complexes contain nicked open circular DNA which can be detected by agarose gel electrophoresis (with ethidium bromide).  […]
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TG1009
Topo II inhibitors have been shown to possess effective antibacterial, antiviral and anticancer activity. Identification of topo II inhibitors and antagonists requires tractable biochemical assays employing purified enzyme.  The Topoisomerase II Drug Screening Kit contains the reagents necessary to screen for agents that affect enzymatic activity.  To allow…
Show more (+)
Topo II inhibitors have been shown to possess effective antibacterial, antiviral and anticancer activity. Identification of topo II inhibitors and antagonists requires tractable biochemical assays employing purified enzyme.  The Topoisomerase II Drug Screening Kit contains the reagents necessary to screen for agents that affect enzymatic activity.  To allow the customer maximum flexibility, some kits include […]
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TG1007
The Topoisomerase IV Drug Screening Kit contains reagents necessary to identify compounds that affect enzyme activity.  Note that kits with a catalog number denoted -A will include E. coli topoisomerase IV enyzme.  This kit will allow detection of two kinds of topoisomerase inhibitors: those that stimulate formation of…
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The Topoisomerase IV Drug Screening Kit contains reagents necessary to identify compounds that affect enzyme activity.  Note that kits with a catalog number denoted -A will include E. coli topoisomerase IV enyzme.  This kit will allow detection of two kinds of topoisomerase inhibitors: those that stimulate formation of cleavable complexes and those that antagonize topoisomerase […]
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TG2001GKIT
This kit contains purified bacterial (E. coli) DNA Gyrase  purified to homogeneity (>98% based on SDS-PAGE). The Gyrase is prepared from overexpressing strains and is supplied as purified holoenzyme in an A2B2 complex.  The enzyme is supplied at the unit concentration given on the quality control data provided…
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This kit contains purified bacterial (E. coli) DNA Gyrase  purified to homogeneity (>98% based on SDS-PAGE). The Gyrase is prepared from overexpressing strains and is supplied as purified holoenzyme in an A2B2 complex.  The enzyme is supplied at the unit concentration given on the quality control data provided with the kit.  It is also stored […]
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TG1017
This kit is designed to allow the customer to screen for agents (drugs, natural products, small molecules, synthetics) that block the catalytic activity of human topoisomerase I (topo I).  The use of high stoichiometric ratios of topo I:DNA induces cleavage complexes without the need to use topo I poisons…
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This kit is designed to allow the customer to screen for agents (drugs, natural products, small molecules, synthetics) that block the catalytic activity of human topoisomerase I (topo I).  The use of high stoichiometric ratios of topo I:DNA induces cleavage complexes without the need to use topo I poisons (camptothecin) which facilitates detection of catalytic […]
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When you become our customer, we become your partner in research. We review your data and offer valuable input. Feel free to contact us for further information about how we can assist your topoisomerase research endeavors.

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