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DR3000-HRCN1.4-Sce
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR…
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DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR can be very beneficial for drug […]
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DR5000
Custom Cell Based Screening Kit for NHEJ contains reagents necessary to create a complete NHEJ reporter system in any animal cell line.  It includes the NHEJ-GFP reporter with a selectable marker and a DS DNA cleavage nuclease to initiate DNA repair.
DR5001-HNHeLa-Sce
This is a HeLa cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and other genes) that affect or impact NHEJ repair. The kit uses GFP as an in situ readout for NHEJ activity in a cell context.
DR3000-HRHeLa-Sce
This is a HeLa cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and genes) that affect or impact the process of HR DNA repair. The kit uses GFP as an in situ readout for the HR pathway.  
DR3050
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication…
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DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase.  […]
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DR5000-HNSH-Sce
This is a cell-based reporter kit that is hosted by a human neuroblastoma cell line (SH-SY5Y) that can grow continuously in vitro and will terminally differentiate.  This provides the opportunity of analyzing NHEJ in growing or terminally differentiated cells in a neuronal lineage.
DR3000-HRHeLa
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication…
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DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase.  […]
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DR5000-HN3T3-Sce
This is a Mouse 3T3 cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and other genes) that affect or impact NHEJ repair. The kit uses GFP as an in situ readout for NHEJ activity in a cell context…
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This is a Mouse 3T3 cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and other genes) that affect or impact NHEJ repair. The kit uses GFP as an in situ readout for NHEJ activity in a cell context.      
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DR3000-HRSH-Sce
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR…
Show more (+)
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR can be very beneficial for drug […]
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DR5000-HNCN1.4
TopoGEN scientists have created a novel, cell based kit to follow NHEJ by simply assaying for the presence of GFP positive cells (Fig 1). DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  Homologous recombination (HR) is a minor pathway but very…
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TopoGEN scientists have created a novel, cell based kit to follow NHEJ by simply assaying for the presence of GFP positive cells (Fig 1). DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  Homologous recombination (HR) is a minor pathway but very important in protecting cells from genotoxicity.  […]
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DR3000-HR3T3-Sce
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication…
Show more (+)
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase.  […]
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DR3000
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication…
Show more (+)
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase.  […]
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TG2000G
Highly purified DNA Gyrase is offered as a holoenzyme (contains both A,B subunits). This is an excellent reagent for supercoiling plasmids in vitro or for novel drug screens.
TG2000GSA
Highly purified S. aureus DNA gyrase is a type II topoisomerase encoded by two genes GyrA and GyrB from staphylococcus aureus.  DNA gyrase is an essential topoisomerase that supercoils DNA through a process of strand breakage/resealing and DNA wrapping.  As a type II enzyme, gyrase is unique in…
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Highly purified S. aureus DNA gyrase is a type II topoisomerase encoded by two genes GyrA and GyrB from staphylococcus aureus.  DNA gyrase is an essential topoisomerase that supercoils DNA through a process of strand breakage/resealing and DNA wrapping.  As a type II enzyme, gyrase is unique in its ability to negatively supercoil a relaxed […]
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TG2023-2
20 ug pRYG-DNA-Data-Sheet
TG2020-1
Assays employing crude extracts for topo II activity based upon relaxation of supercoiled DNA can be complicated due to the presence of topo I in partially purified fractions.  Additional complications arise with contaminating nuclease activity (due to Mg++) which degrade or nick the supercoiled substrate.  These problems can…
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Assays employing crude extracts for topo II activity based upon relaxation of supercoiled DNA can be complicated due to the presence of topo I in partially purified fractions.  Additional complications arise with contaminating nuclease activity (due to Mg++) which degrade or nick the supercoiled substrate.  These problems can be avoided by using a catenated DNA […]
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TG2018-1
Assays employing crude extracts for topo II activity based upon relaxation of supercoiled DNA can be complicated due to the presence of topo I in partially purified fractions.  Additional complications arise with contaminating nuclease activity (due to Mg++) which degrade or nick the supercoiled substrate.  These problems can…
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Assays employing crude extracts for topo II activity based upon relaxation of supercoiled DNA can be complicated due to the presence of topo I in partially purified fractions.  Additional complications arise with contaminating nuclease activity (due to Mg++) which degrade or nick the supercoiled substrate.  These problems can be avoided by using a catenated DNA […]
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TG2013
Kinetoplast DNA (kDNA) is the ideal substrate for topoisomerase II assays because it is specific for type II reaction mechanisms.  Researchers can even assay for a type II enzyme in the presence of large excess of topoisomerase I.  Thus, kDNA works well to quantify type II activity in…
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Kinetoplast DNA (kDNA) is the ideal substrate for topoisomerase II assays because it is specific for type II reaction mechanisms.  Researchers can even assay for a type II enzyme in the presence of large excess of topoisomerase I.  Thus, kDNA works well to quantify type II activity in crude cell extracts, which are frequently overloaded […]
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TG2030
This plasmid is a perfect substrate for assaying any topoisomerase.  pHOT-1 is relatively small (<3KB) which is ideal for displaying intermediate topoisomers.  Since all topoisomerases display degenerate DNA binding and cleavage sequences, pHOT-1 will effectively support activity for a wide array of topoisomerase.  Supercoiled pHOT-1 is…
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This plasmid is a perfect substrate for assaying any topoisomerase.  pHOT-1 is relatively small (<3KB) which is ideal for displaying intermediate topoisomers.  Since all topoisomerases display degenerate DNA binding and cleavage sequences, pHOT-1 will effectively support activity for a wide array of topoisomerase.  Supercoiled pHOT-1 is a scaled-down derivative of pBR322 and optimized for higher […]
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TG2035
Relaxed pHOT-1 DNA is suited to assaying the supercoiling activity of DNA gyrase.  It is also useful for assaying alterations in DNA linking number for assessing intercalation.    
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