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Topo I
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PRODUCT ID | Product Info | Description | Purchase |
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TG4103 |
10-Hydroxy Camptothecin has shown promising activity against a range of tumour types. This CPT derivative causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single and double strand breaks. TopoGEN provides this reagent as a control poison/inhibitor of… Show more (+) 10-Hydroxy Camptothecin has shown promising activity against a range of tumour types. This CPT derivative causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single and double strand breaks. TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase I. For in vitro […] Show less (-) |
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TG4104 |
9-Amino-20-(R,S)-camptothecin (also known as 9-amino campthecin) is an analogue of camptothecin. Like other CPT congeners, it shows some promising activity against a range of tumor types. This compound causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA… Show more (+) 9-Amino-20-(R,S)-camptothecin (also known as 9-amino campthecin) is an analogue of camptothecin. Like other CPT congeners, it shows some promising activity against a range of tumor types. This compound causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single and double strand breaks. TopoGEN […] Show less (-) |
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TG4102 |
20(S)camptothecin has shown promising activity against a range of tumour types. This CPT derivative causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single and double strand breaks. TopoGEN provides this reagent as a control poison/inhibitor… Show more (+) 20(S)camptothecin has shown promising activity against a range of tumour types. This CPT derivative causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single and double strand breaks. TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase I. For in vitro cleavage […] Show less (-) |
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TG4110 |
Camptothecin is a topo I poison that both inhibits enzyme activity and stabilizes formation of topo I cleavage complexes (Hsiang et al J. Biol. Chem. 260:14873-14878, 1985). TopoGEN provides this reagent as a control inhibitor/poison of topoisomerase I. For in vitro cleavage detection, we recommend that the drug… Show more (+) Camptothecin is a topo I poison that both inhibits enzyme activity and stabilizes formation of topo I cleavage complexes (Hsiang et al J. Biol. Chem. 260:14873-14878, 1985). TopoGEN provides this reagent as a control inhibitor/poison of topoisomerase I. For in vitro cleavage detection, we recommend that the drug be tested in the range 100 uM; […] Show less (-) |
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TG4100 |
Hycamtin (topotecan hydrochloride) is a semi-synthetic derivative of camptothecin and is an anti-tumor drug that targets topo I and is a topo I poison (induces cleavage complexes). |
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