PUBLICATIONS

Meelad M. Dawlaty, Liviu Malureanu, Karthik B. Jeganathan, Esther Kao, Claudio Sustmann, Samuel Tahk, Ke Shua, Rudolf Grosschedl, and Jan M. van Deursen Resolution of Sister Centromeres Requires RanBP2-Mediated SUMOylation of Topoisomerase IIa Cell 2008 133: 103-115.

Darren J. Burgess, Jason Doles, Lars Zender, Wen Xue, Beicong Ma, W. Richard McCombie, Gregory J. Hannon, Scott W. Lowe, and Michael T. Hemann Topoisomerase Levels Determine Chemotherapy Response In Vitro and In Vivo PNAS communicated by Michael H. Wigler, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, April 2008.

Cai Bowen, August Stuart, Jeong-Ho Ju, Jenny Tuan, Josip Blonder, Thomas P. Conrads, Timothy D. Veenstra, and Edward P. Gelmann NKX3.1 Homeodomain Protein Binds to Topoisomerase I and Enhances Its Activity Cancer Res. 2007 67: 455-464.

Anthony Maxwell, Nicolas P. Burton and Natasha O’Hagan High-throughput Assays for DNA Gyrase and other Topoisomerases Nucleic Acids Research 2006 34: No. 15 e104.

Alexandre Santos, Loreley Calvet, Marie-Josee Terrier-Lacombe, Annette Larsen, Jean Bénard, Corinne Pondarré, Geneviève Aubert, Jackie Morizet, François Lavelle, and Gilles Vassal In Vivo Treatment with CPT-11 Leads to Differentiation of Neuroblastoma Xenografts and Topoisomerase I Alterations Cancer Res. 2004 64: 3223-3229.

Hanlin Gao, Edith F. Yamasaki, Kenneth K. Chan, Linus L. Shen, and Robert M. Snapka Chloroquinoxaline Sulfonamide (NSC 339004) Is a Topoisomerase II/ß Poison Cancer Res. 2000 60: 5937-5940.

WuCarrie Walowsky, David J. Fitzhugh, Irene B. Castaño, Justina Y. Ju, Nikki A. Levin, and Michael F. Christman The Topoisomerase-related Function Gene TRF4 Affects Cellular Sensitivity to the Antitumor Agent Camptothecin J. Biol. Chem. 1999 274: 7302-7308.

Young Kwon, Beom Sic Shin, and In Kwon Chung The p53 Tumor Suppressor Stimulates the Catalytic Activity of Human Topoisomerase II by Enhancing the Rate of ATP Hydrolysis
J. Biol. Chem. 2000 275: 18503-18510.

Lars H. Jensen, Karin C. Nitiss, Angela Rose, Jiaowang Dong, Junfang Zhou, Tao Hu, Neil Osheroff, Peter B. Jensen, Maxwell Sehested, and John L. Nitiss A Novel Mechanism of Cell Killing by Anti-topoisomerase II Bisdioxopiperazines J. Biol. Chem. 2000 275: 2137-2146.

Yoshiyuki Mizushina, Shinji Kamisuki, Takeshi Mizuno, Masaharu Takemura, Hitomi Asahara, Stuart Linn, Toyofumi Yamaguchi, Akio Matsukage, Fumio Hanaoka, Shonen Yoshida, Mineo Saneyoshi, Fumio Sugawara, and Kengo Sakaguchi Dehydroaltenusin: A mammalian DNA polymerase alpha inhibitor
Papers in Press: J. Biol. Chem. published August 14, 2000 as 10.1074/jbc.M006096200.

Koichi Ayukawa, Shun’ichiro Taniguchi, Junya Masumoto, Shigenari Hashimoto, Haritha Sarvotham, Astushi Hara, Toshifmi Aoyama, and Junji Sagara La autoantigen is cleaved in the COOH-terminus and loses the nuclear localization signal (NLS) during apoptosis Papers in Press: J. Biol. Chem. published July 26, 2000 as 10.1074/jbc.M003673200.

Ebba U. Kurz, Kelly B. Leader, David J. Kroll, Michael Clark, and Frank Gieseler Modulation of Human DNA Topoisomerase II Function by Interaction with 14-3-3 J. Biol. Chem. 2000 275: 13948-13954.

Anton Tevelev and David G. Schatz Intermolecular V(D)J Recombination J. Biol. Chem. 2000 275: 8341-8348.

Piotr Widlak, Peng Li, Xiaodong Wang, and William T. Garrard Cleavage Preferences of the Apoptotic Endonuclease DFF40 (Caspase-activated DNase or Nuclease) on Naked DNA and Chromatin Substrates J. Biol. Chem. 2000 275: 8226-8232.

Jiaowang Dong, Jerrylaine Walker, and John L. Nitiss A Mutation in Yeast Topoisomerase II That Confers Hypersensitivity to Multiple Classes of Topoisomerase II Poisons J. Biol. Chem. 2000 275: 7980-7987.

Pearl Nurse, Soon Bahng, Elena Mossessova, and Kenneth J. Marians Mutational Analysis of Escherichia coli Topoisomerase IV. II. ATPase NEGATIVE MUTANTS OF ParE INDUCE HYPER-DNA CLEAVAGE J. Biol. Chem. 2000 275: 4104-4111.

Junya Masumoto, Shun’ichiro Taniguchi, Koichi Ayukawa, Haritha Sarvotham, Tatsuya Kishino, Norio Niikawa, Eiko Hidaka, Tsutomu Katsuyama, Tsukasa Higuchi, and Junji Sagara ASC, a Novel 22-kDa Protein, Aggregates during Apoptosis of Human Promyelocytic Leukemia HL-60 Cells J. Biol. Chem. 1999 274: 33835-33838.

Lothar Halmer, Birgit Vestner, and Claudia Gruss Involvement of Topoisomerases in the Initiation of Simian Virus 40 Minichromosome Replication J. Biol. Chem. 1998 273: 34792-34798.

Michelle Sabourin, Jo Ann Wilson Byl, S. Erin Hannah, John L. Nitiss, and Neil Osheroff A Mutant Yeast Topoisomerase II (top2G437S) with Differential Sensitivity to Anticancer Drugs in the Presence and Absence of ATP J. Biol. Chem. 1998 273: 29086-29092.

Charles Redwood, Sally L. Davies, Nicholas J. Wells, Andrew M. Fry, and Ian D. Hickson Casein Kinase II Stabilizes the Activity of Human Topoisomerase II in a Phosphorylation-independent Manner J. Biol. Chem. 1998 273: 3635-3642

Robert C. Rintoul; Sarah M. Moore; Alison C. MacKinnon; Donald Salter; Chin Choo; Edwin R. Chilvers;
Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo Nature Medicine Volume 5 Number 6 Page 662 – 668 (1999)

Ina Rhee; Kam-Wing Jair; Ray-Whay Chiu Yen; Christoph Lengauer; James G. Herman; Kenneth W. Kinzler; CpG methylation is maintained in human cancer cells lacking DNMT1
Nature Volume 404 Number 6781 Page 1003 – 1007 (2000)

Philippe Pourquier, Yuji Takebayashi, Yoshimasa Urasaki, Christopher Gioffre, Glenda Kohlhagen, and Yves Pommier Induction of topoisomerase I cleavage complexes by 1–D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells PNAS 97: 1885-1890.

Cynthia M. Simbulan-Rosenthal, Bassem R. Haddad, Dean S. Rosenthal, Zoë Weaver, Allen Coleman, RuiBai Luo, Hannah M. Young, Zhao-Qi Wang, Thomas Ried, and Mark E. Smulson. Chromosomal aberrations in PARP/ mice: Genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA PNAS 96: 13191-13196.

Karen M. Sommer, Lucinda I. Chen, Piper M. Treuting, Lynne T. Smith, and Karen Swisshelm Elevated retinoic acid receptor 4 protein in human breast tumor cells with nuclear and cytoplasmic localization PNAS 96: 8651-8656.

Eduardo J. Martinez, Takashi Owa, Stuart L. Schreiber, and E. J. Corey Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743 PNAS 96: 3496-3501.

Yan Kwok, Qingping Zeng, and Laurence H. Hurley Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites PNAS 95: 13531-13536.

Janet D. Siliciano, Christine E. Canman, Yoichi Taya, Kazuyasu Sakaguchi, Ettore Appella, and Michael B. Kastan DNA damage induces phosphorylation of the amino terminus of p53 Genes Dev. 1997 11: 3471-3481.

Paul R. Andreassen, Françoise B. Lacroix, and Robert L. Margolis Chromosomes with Two Intact Axial Cores Are Induced by G2 Checkpoint Override: Evidence That DNA Decatenation Is not Required to Template the Chromosome Structure J. Cell Biol. 1997 136: 29-43.

Han-Mo Koo, Marcia Gray-Goodrich, Glenda Kohlhagen, Mary Jane McWilliams, Michael Jeffers, Anne Vaigro-Wolff, W. Gregory Alvord, Anne Monks, Kenneth D. Paull, Yves Pommier, and George F. Vande Woude The ras Oncogene-Mediated Sensitization of Human Cells to Topoisomerase II Inhibitor-Induced Apoptosis J Natl Cancer Inst 1999 91: 236-244.

Shigehiro Ohdo, Tomoko Makinosumi, Takashi Ishizaki, Eiji Yukawa, Shun Higuchi, Shigeyuki Nakano, and Nobuya Ogawa Cell Cycle-Dependent Chronotoxicity of Irinotecan Hydrochloride in Mice
J Pharmacol Exp Ther 1997 283: 1383-1388.

France Carrier, Philippe T. Georgel, Philippe Pourquier, Mellissa Blake, H. Udo Kontny, Michael J. Antinore, Marzia Gariboldi, Timothy G. Myers, John N. Weinstein, Yves Pommier, and Albert J. Fornace, Jr. Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin
Mol. Cell. Biol. 1999 19: 1673-1685.

Purificación Muñoz, Malgorzata Z. Zdzienicka, Jean-Marie Blanchard, and Jacques Piette Hypersensitivity of Ku-Deficient Cells toward the DNA Topoisomerase II Inhibitor ICRF-193 Suggests a Novel Role for Ku Antigen during the G2 and M Phases of the Cell Cycle
Mol. Cell. Biol. 1998 18: 5797-5808

Q. Q. Pu and W. R. Bezwoda Induction of Alkylator (Melphalan) Resistance in HL60 Cells Is Accompanied by Increased Levels of Topoisomerase II Expression and Function
Mol Pharmacol 1999 56: 147-153.

Tatiana Syrovets, Berthold Büchele, Erk Gedig, Joseph R. Slupsky, and Thomas Simmet Acetyl-Boswellic Acids Are Novel Catalytic Inhibitors of Human Topoisomerases I and II Mol Pharmacol 2000 58: 71-81

Brian B. Hasinoff, Andrew M. Creighton, Hanna Kozlowska, Padmakumari Thampatty, William P. Allan, and Jack C. Yalowich Mitindomide Is a Catalytic Inhibitor of DNA Topoisomerase II That Acts at the Bisdioxopiperazine Binding Site Mol Pharmacol 1997 52: 839-845.

Jean-Pierre Henichart, Michael J. Waring, Jean-Francois Riou, William A. Denny, and Christian Bailly Copper-Dependent Oxidative and Topoisomerase II-Mediated DNA Cleavage by a Netropsin/4-(9-acridinylamino)methanesulfon-m-anisidide Combilexin Mol Pharmacol 1997 51: 448-461.

Nozomi Niitsu, Takashi Kasukabe, Akihiro Yokoyama, Junko Okabe-Kado, Yuri Yamamoto-Yamaguchi, Masanori Umeda, and Yoshio Honma Anticancer Derivative of Butyric Acid (Pivalyloxymethyl Butyrate) Specifically Potentiates the Cytotoxicity of Doxorubicin and Daunorubicin through the Suppression of Microsomal Glycosidic Activity Mol Pharmacol 2000 58: 27-36.

Sandhiya Patel, Beatrice A. Keller, and L. Mark Fisher Mutations at Arg486 and Glu571 in Human Topoisomerase II Confer Resistance to Amsacrine: Relevance for Antitumor Drug Resistance in Human Cells Mol Pharmacol 2000 57: 784-791.

Susan E. Morgan, Rhonda S. Cadena, Susana C. Raimondi, and William T. Beck Selection of Human Leukemic CEM Cells for Resistance to the DNA Topoisomerase II Catalytic Inhibitor ICRF-187 Results in Increased Levels of Topoisomerase II and Altered G2/M Checkpoint and Apoptotic Responses Mol Pharmacol 2000 57: 296-307.

Bogdan Vladu, Jan M. Woynarowski, Govindarajan Manikumar, Mansukhlal C. Wani, Monroe E. Wall, Daniel D. Von Hoff, and Randy M. Wadkins 7- and 10-Substituted Camptothecins: Dependence of Topoisomerase I-DNA Cleavable Complex Formation and Stability on the 7- and 10-Substituents
Mol Pharmacol 2000 57: 243-251

Zhe-Sheng Chen, Tatsuhiko Furukawa, Tomoyuki Sumizawa, Kenji Ono, Kazumitsu Ueda, Kiyotomo Seto, and Shin-Ichi Akiyama ATP-Dependent Efflux of CPT-11 and SN-38 by the Multidrug Resistance Protein (MRP) and Its Inhibition by PAK-104P Mol Pharmacol 1999 55: 921-928

Sutapa Ray, Banasri Hazra, Bidyottam Mittra, Aditi Das, and Hemanta K. Majumder Diospyrin, A Bisnaphthoquinone: A Novel Inhibitor of Type I DNA Topoisomerase of Leishmania donovani
Mol Pharmacol 1998 54: 994-999

E. Willmore, A. J. Frank, K. Padget, M. J. Tilby, and C. A. Austin Etoposide Targets Topoisomerase II and II in Leukemic Cells: Isoform-Specific Cleavable Complexes Visualized and Quantified In Situ by a Novel Immunofluorescence Technique Mol Pharmacol 1998 54: 78-85

Tsvetan G. Gantchev and Darel J. Hunting The Ortho-Quinone Metabolite of the Anticancer Drug Etoposide (VP-16) Is a Potent Inhibitor of the Topoisomerase II/DNA Cleavable Complex
Mol Pharmacol 1998 53: 422-428

Noboru Fujii, Yoshinori Yamashita, Tamio Mizukami, and Hirofumi Nakano Correlation between the Formation of Cleavable Complex with Topoisomerase I and Growth-Inhibitory Activity for Saintopin-Type Antibiotics Mol Pharmacol 1997 51: 269-276

You-Chan Kim, Junho Lee, and Hyeon-Sook Koo Functional characterization of Caenorhabditis elegans DNA topoisomerase III Nucl. Acids. Res. 2000 28: 2012-2017.

Ian Morrissey and John George Activities of Fluoroquinolones against Streptococcus pneumoniae Type II Topoisomerases Purified as Recombinant Proteins Antimicrob. Agents Chemother. 1999 43: 2579-2585.

Anne Y. C. Saiki, Linus L. Shen, Chih-Ming Chen, John Baranowski, and Claude G. Lerner

DNA Cleavage Activities of Staphylococcus aureus Gyrase and Topoisomerase IV Stimulated by Quinolones and 2-Pyridones Antimicrob. Agents Chemother. 1999 43: 1574-1577

Xiao-Su Pan and L. Mark Fisher Streptococcus pneumoniae DNA Gyrase and Topoisomerase IV: Overexpression, Purification, and Differential Inhibition by Fluoroquinolones
Antimicrob. Agents Chemother. 1999 43: 1129-1136

Masaya Takei, Hideyuki Fukuda, Tokutaro Yasue, Masaki Hosaka, and Yasuo Oomori Inhibitory Activities of Gatifloxacin (AM-1155), a Newly Developed Fluoroquinolone, against Bacterial and Mammalian Type II Topoisomerases Antimicrob. Agents Chemother. 1998 42: 2678-2681

Takaaki Akasaka, Seiko Kurosaka, Yoko Uchida, Mayumi Tanaka, Kenichi Sato, and Isao Hayakawa Antibacterial Activities and Inhibitory Effects of Sitafloxacin (DU-6859a) and Its Optical Isomers against Type II Topoisomerases Antimicrob. Agents Chemother. 1998 42: 1284-1287

Alexander A. Shtil, Joel G. Turner, John Durfee, William S. Dalton, and Hua Yu Cytokine-Based Tumor Cell Vaccine Is Equally Effective Against Parental and Isogenic Multidrug-Resistant Myeloma Cells: The Role of Cytotoxic T Lymphocytes Blood 1999 93: 1831-1837

Masako Aoyama, Dale R. Grabowski, Richard J. Isaacs, Kim A. Krivacic, Lisa A. Rybicki, Ronald M. Bukowski, Mahrukh K. Ganapathi, Ian D. Hickson, and Ram Ganapathi Altered Expression and Activity of Topoisomerases During All-Trans Retinoic Acid-Induced Differentiation of HL-60 Cells
Blood 1998 92: 2863-2870

Jingxin Wang, Masanobu Kobayashi, Keisuke Sakurada, Masahiro Imamura, Tetsuya Moriuchi, and Masuo Hosokawa Possible Roles of an Adult T-Cell Leukemia (ATL)-Derived Factor/Thioredoxin in the Drug Resistance of ATL to Adriamycin Blood 1997 89: 2480-2487

Heather M. Smith and Andrew J. Grosovsky PolyADP-ribose-mediated regulation of p53 complexed with topoisomerase I following ionizing radiation Carcinogenesis 1999 20: 1439-1444

erzberger et al. (1998) Induction of apoptosis in MCF-7:WS8 Breast Cancer Cells By B-Lapachone. Cancer Research 58:1876-1885

Gupta, M., Abdel-Mageed, M., Hoki, Y., Kohlhagen, G., Paull, K., and Pommier, Y. (1995) Eukaryotic DNA topoisomerases mediated DNA cleavage induced by a new inhibitor: NSC 665517 Molecular Pharmacology 48:658-665

Permana, P.A., et al. (1994) Quinobenoxazines: A class of novel antitumor quinolones and potent mammalian DNA topoisomerase II Catalytic inhibitors. Biochemistry 33: 11333-11339

Gorbsky, G.J. (1994) Cell cycle progression and chromosome segregation in mammalian cells cultured in the presence of the topo II inhibitors ICRF-187 and ICRF-159. Cancer Research 54:1042-1048

Goswami, P.C., et al., (1996) The cell cycle coupled expression of topo II alpha during S phase is regulated by mRNA stability and is disrupted by heat shock or ionizing radiation. Molec. Cell. Biol. 16:1500-1508

Bousquet. P.F. (1995) Preclinical Evaluation of LU 79553: A novel Bis-naphthalimide with potent antitumor activity. Cancer Research 55:1176-1180.

Bechert, T., Diekmann, and Arndt-Jovin, D.J. (1994) Human 170 kDa and 18- kDa bind preferentially to curved and left-handed linear DNA. J. Biomolec. Struct. and Dynamics 12:605-616

Eder. J.P. et al., (1995) DNA topo II alpha expression is associated with alkylating agent resistance. Cancer Research 55:6109-6116.

Gupta, R. et al. (1996) Design, synthesis and topo II inhibition activity of 4′ demethylepipodophylotoxin-lexitropsin conjugates. Anti-cancer Drug Design 11:325-338

Spitzner, J.R. et al., (1995) Analysis of eukaryotic topo II cleavage in the presence of quinolone CP-115,953 reveals drug dependent and independent recognition elements. Molec. Pharm. 48:238-249.

Alflalo, E., Iftach, S., Segal, S, Gazit, A and Priel, E. (1994). Inhibition of topo I activity by tyrphostin derivatives, protein tyrosine kinase blockers: Mechanism of Action. Cancer Res. 54:5138-5142

Devray, R et al. (1996) Synthesis of a series of cytotoxic 2-acyl-1,2-dihyroellipticines which inhibit topo II. Anti-cancer Drug Design 11:311-324.

Barrows, L.R. et al. (1993) Makulavamines, marine natural products, are active anticancer agents and DNA topo II inhibitors. Anticancer Drug Design 8:333-347.

Felix, C.A., Lange, B., Hosler, M. Fertala, J and Bjornsti, M. (1995) Chromosome band 11q23 translocation breakpoints are DNA topoisomerase II cleavage sites. Cancer Res. 55:4287-4292

Brana, M.F. et al. (1993) Bis-napthalimides: a new class of antitumor agents.Anti-cancer Drug Design 8:257-268

Meikle, I. et al. (1995) Identification of anthracenyl-dipeptide conjugates as novel topo I and II inhibitors and their evalutaion as potential drugs. Anticancer Drug Design 10:515-527

Alami-Ouahabi, N. et al. (1996) The testis-specific high mobility group Protein, a phosphorylation-dependent DNA packaging factor of elongating and condensing spermatids. Molec. Cell. Biol. 16:3720-3729.

van der Zee, A., Jong, S. Keith, W.N., Hollema, Boonstra, H. and de Vries, E. 1994) Quantitative and qualitative aspects of topo I and IIa and b in untreated and platinum/cyclophosphamide treated malignant ovarian tumors. Cancer Res. 54:749-755.

Taniguchi, K, et al. (1996) Drug-induced down-regulation of topo I in human epidermoid cancer cells resistant to saintopin and camptothecins. Cancer Res. 56:2348-2354

Simbulan-Rosenthal, C.M et al. (1996) The expression of poly(ADP-ribose) polymerase during differentiation-linked DNA replication reveals that it is a component of the multiprotein DNA replication complex. Biochemistry 35:11622-11633

Saitoh, Y and Laemmli, U.K. (1994) Metaphase Chromosome Structure: Bands arise from a differential folding path of the hightly AT-rich scaffold Cell 76:609-622

Gaudio, M.M. and Risley, M.S. (1994) Topo II expression and VM26 induction of DNA breaks during spermatogenesis in X. laevis J. Cell Sci. 107:2887-2898

Stammler, G., Sauerbery, A. and Volm, M. (1994) Determination of DNA topo II in newly diagnosed childhood acute lymphoblastic leukemia by immunocytochemistry and RT-PCR. Cancer letters 84:141-147

Mark E. Smulson* ; Regulation of the Expression or Recruitment of Components of the DNA Synthesome by Poly(ADP-Ribose) Polymerase, Biochemistry; 1998; 37(26); 9363-9370.

Jean-Claude D’Halluin* ; The DNA Binding Domain of the Human c-Abl Tyrosine Kinase Preferentially Binds to DNA Sequences Containing an AAC Motif and to Distorted DNA Structures, Biochemistry; 1998; 37(17); 6065-6076.

L. Angenot ; The DNA Intercalating Alkaloid Cryptolepine Interferes with Topoisomerase II and Inhibits Primarily DNA Synthesis in B16 Melanoma Cells, Biochemistry; 1998; 37(15); 5136-5146.

Neil Osheroff ; Covalent Attachment of Ethidium to DNA Results in Enhanced Topoisomerase II-Mediated DNA Cleavage, Biochemistry; 1997; 36(50); 15884-15891

Mark E. Smulson* ; The Expression of Poly(ADP-ribose) Polymerase during Differentiation-Linked DNA Replication Reveals That It Is a Component of the Multiprotein DNA Replication Complex, Biochemistry; 1996; 35(36); 11622-11633.

Jean-François Riou* ; Modulation of DNA Topoisomerase I Activity by p53, Biochemistry; 1996; 35(18); 5778-5786.

Cindy Harrington, Yun Lan, and Steven A. Akman The Identification and Characterization of a G4-DNA Resolvase Activity J. Biol. Chem. 1997 272: 24631-24636.

Timothy R. Hammonds and Anthony Maxwell The DNA Dependence of the ATPase Activity of Human DNA Topoisomerase II J. Biol. Chem. 1997 272: 32696-32703.

Caterina Allera, Giuseppe Lazzarini, Eligio Patrone, Ingles Alberti, Paola Barboro, Paola Sanna, Antonella Melchiori, Silvio Parodi, and Cecilia Balbi. The Condensation of Chromatin in Apoptotic Thymocytes Shows a Specific Structural Change J. Biol. Chem. 1997 272: 10817-10822.

Naiyer Azam, Julie E. Dixon, and Paul D. Sadowski Topological Analysis of the Role of Homology in Flp-mediated Recombination J. Biol. Chem. 1997 272: 8731-8738.

Ajit K. Bharti, Mark O. J. Olson, Donald W. Kufe, and Eric H. Rubin Identification of a Nucleolin Binding Site in Human Topoisomerase I J. Biol. Chem. 1996 271: 1993-1997.

J. R. Spitzner, I. K. Chung, and Mark T. Muller Determination of 5` and 3` DNA Triplex Interference Boundaries Reveals the Core DNA Binding Sequence for Topoisomerase II J. Biol. Chem. 1995 270: 5932-5943.

Andreassen, P.R., et al., Chromosomes with two intact axial cores are induced by G2 checkpoint override: Evidence that DNA decatenation is not required to template the chromsome structure. 1997. J. Cell. Biol. 139:29-43

Akasaka, T., et al. Antibacterial activites and inhibitory effects of sitafloxacin and its opitmal isomers vs. type II topoisomerase. Antimicrob. Agenst Chemother. 1998 42:1284-1289

Kampranis, S. and Maxwell. Conversion of DNA gyrase into a conventional type II topoisomerase PNAS 1996. 93:14416-14421

Munoz, P. et al. Hypersensitivityof Ku-deficient cells toward the DNA topo II inhibitor ICRF-193 suggests a novel reole for Ku antigen during the G2 and M phases of the cell cycle. Molec. Cell. Biol. 1998. 18:5797-5808

Cindy Harrington, Yun Lan, and Steven A. Akman The Identification and Characterization of a G4-DNA Resolvase Activity J. Biol. Chem. 1997 272: 24631-24636

Lothar Halmer, Birgit Vestner, and Claudia Gruss Involvement of Topoisomerases in the Initiation of Simian Virus 40 Minichromosome Replication J. Biol. Chem. 1998 273: 34792-34798

Timothy R. Hammonds and Anthony Maxwell The DNA Dependence of the ATPase Activity of Human DNA Topoisomerase II J. Biol. Chem. 1997 272: 32696-32703

Caterina Allera, Giuseppe Lazzarini, Eligio Patrone, Ingles Alberti, Paola Barboro, Paola Sanna, Antonella Melchiori, Silvio Parodi, and Cecilia Balbi The Condensation of Chromatin in Apoptotic Thymocytes Shows a Specific Structural Change J. Biol. Chem. 1997 272: 10817-10822

Naiyer Azam, Julie E. Dixon, and Paul D. Sadowski Topological Analysis of the Role of Homology in Flp-mediated Recombination J. Biol. Chem. 1997 272: 8731-8738

Ajit K. Bharti, Mark O. J. Olson, Donald W. Kufe, and Eric H. Rubin Identification of a Nucleolin Binding Site in Human Topoisomerase I J. Biol. Chem. 1996 271: 1993-1997

Genes & Dev. 1998 12: 149-162.Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 Narayan V. Iyer, Lori E. Kotch, Faton Agani, Sandra W. Leung, Erik Laughner, Roland H. Wenger, Max Gassmann, John D. Gearhart, Ann M. Lawler, Aimee Y. Yu, and Gregg L. Semenza

PNAS 1999 96: 13191-13196. Chromosomal aberrations in PARP/ mice: Genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA Cynthia M. Simbulan-Rosenthal, Bassem R. Haddad, Dean S. Rosenthal, Zoë Weaver, Allen Coleman, RuiBai Luo, Hannah M. Young, Zhao-Qi Wang, Thomas Ried, and Mark E. Smulson

Antimicrob. Agents Chemother. 1999 43: 2579-2585. Activities of Fluoroquinolones against Streptococcus pneumoniae Type II Topoisomerases Purified as Recombinant ProteinsIan Morrissey and John George

PNAS 1999 96: 10355-10360. The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53Céline Gobert, Andrzej Skladanowski, and Annette K. Larse

Carcinogenesis 1999 20: 1439-1444.PolyADP-ribose-mediated regulation of p53 complexed with topoisomerase I following ionizing radiationHeather M. Smith and Andrew J. GrosovskyPNAS

PNAS 1999 96: 8651-8656. Elevated retinoic acid receptor 4 protein in human breast tumor cells with nuclear and cytoplasmic localizationKaren M. Sommer, Lucinda I. Chen, Piper M. Treuting, Lynne T. Smith, and Karen Swisshelm

PNAS 1999 96: 7859-7864. Functional interaction between human topoisomerase II and retinoblastoma protein Uppoor G. Bhat, Pradip Raychaudhuri, and William T. Beck

Antimicrob. Agents Chemother. 1999 43: 1574-1577. DNA Cleavage Activities of Staphylococcus aureus Gyrase and Topoisomerase IV Stimulated by Quinolones and 2-PyridonesAnne Y. C. Saiki, Linus L. Shen, Chih-Ming Chen, John Baranowski, and Claude G. Lerner

Mol. Pharmacol. 1999 56: 147-153. Induction of Alkylator (Melphalan) Resistance in HL60 Cells Is Accompanied by Increased Levels of Topoisomerase II Expression and Function Q. Q. Pu and W. R. Bezwoda

Antimicrob. Agents Chemother. 1999 43: 1129-1136. Streptococcus pneumoniae DNA Gyrase and Topoisomerase IV: Overexpression, Purification, and Differential Inhibition by Fluoroquinolones Xiao-Su Pan and L. Mark Fisher

Mol. Pharmacol. 1999 55: 921-928. ATP-Dependent Efflux of CPT-11 and SN-38 by the Multidrug Resistance Protein (MRP) and Its Inhibition by PAK-104P Zhe-Sheng Chen, Tatsuhiko Furukawa, Tomoyuki Sumizawa, Kenji Ono, Kazumitsu Ueda, Kiyotomo Seto, and Shin-Ichi Akiyama

PNAS 1999 96: 3496-3501. Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743 Eduardo J. Martinez, Takashi Owa, Stuart L. Schreiber, and E. J. Corey

Blood 1999 93: 1831-1837. Cytokine-Based Tumor Cell Vaccine Is Equally Effective Against Parental and Isogenic Multidrug-Resistant Myeloma Cells: The Role of Cytotoxic T Lymphocytes Alexander A. Shtil, Joel G. Turner, John Durfee, William S. Dalton, and Hua Yu

J. Biol. Chem 1999 274: 7302-7308. The Topoisomerase-related Function Gene TRF4 Affects Cellular Sensitivity to the Antitumor Agent Camptothecin Carrie Walowsky, David J. Fitzhugh, Irene B. Castaño, Justina Y. Ju, Nikki A. Levin, and Michael F. Christman

Mol. Cell. Biol. 1999 19: 1673-1685. Gadd45, a p53-Responsive Stress Protein, Modifies DNA Accessibility on Damaged Chromatin France Carrier, Philippe T. Georgel, Philippe Pourquier, Mellissa Blake, H. Udo Kontny, Michael J. Antinore, Marzia Gariboldi, Timothy G. Myers, John N. Weinstein, Yves Pommier, and Albert J. Fornace, Jr.

J. Natl. Cancer Inst. 1999 91: 236-244. The ras Oncogene-Mediated Sensitization of Human Cells to Topoisomerase II Inhibitor-Induced Apoptosis Han-Mo Koo, Marcia Gray-Goodrich, Glenda Kohlhagen, Mary Jane McWilliams, Michael Jeffers, Anne Vaigro-Wolff, W. Gregory Alvord, Anne Monks, Kenneth D. Paull, Yves Pommier, and George F. Vande Woude

J. Biol. Chem 1998 273: 34792-34798. Involvement of Topoisomerases in the Initiation of Simian Virus 40 Minichromosome Replication Lothar Halmer, Birgit Vestner, and Claudia Gruss

Mol. Pharmacol. 1998 54: 994-999. Diospyrin, A Bisnaphthoquinone: A Novel Inhibitor of Type I DNA Topoisomerase of Leishmania donovani Sutapa Ray, Banasri Hazra, Bidyottam Mittra, Aditi Das, and Hemanta K. Majumder

PNAS 1998 95: 13531-13536. Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites Yan Kwok, Qingping Zeng, and Laurence H. Hurley

Plant Physiology 1998 118: 1029-1038. A Chloroplast DNA Helicase II from Pea That Prefers Fork-Like Replication Structures Narendra Tuteja and Tuan-Nghia Phan

J. Biol. Chem 1998 273: 29086-29092. A Mutant Yeast Topoisomerase II (top2G437S) with Differential Sensitivity to Anticancer Drugs in the Presence and Absence of ATP Michelle Sabourin, Jo Ann Wilson Byl, S. Erin Hannah, John L. Nitiss, and Neil Osheroff

Blood 1998 92: 2863-2870. Altered Expression and Activity of Topoisomerases During All-Trans Retinoic Acid-Induced Differentiation of HL-60 Cells Masako Aoyama, Dale R. Grabowski, Richard J. Isaacs, Kim A. Krivacic, Lisa A. Rybicki, Ronald M. Bukowski, Mahrukh K. Ganapathi, Ian D. Hickson, and Ram Ganapathi

Mol. Cell. Biol. 1998 18: 5797-5808. Hypersensitivity of Ku-Deficient Cells toward the DNA Topoisomerase II Inhibitor ICRF-193 Suggests a Novel Role for Ku Antigen during the G2 and M Phases of the Cell Cycle Purificación Muñoz, Malgorzata Z. Zdzienicka, Jean-Marie Blanchard, and Jacques Piette

Antimicrob. Agents Chemother. 1998 42: 2678-2681. Inhibitory Activities of Gatifloxacin (AM-1155), a Newly Developed Fluoroquinolone, against Bacterial and Mammalian Type II Topoisomerases Masaya Takei, Hideyuki Fukuda, Tokutaro Yasue, Masaki Hosaka, and Yasuo Oomori

Mol. Pharmacol. 1998 54: 78-85. Etoposide Targets Topoisomerase II and II in Leukemic Cells: Isoform-Specific Cleavable Complexes Visualized and Quantified In Situ by a Novel Immunofluorescence Technique E. Willmore, A. J. Frank, K. Padget, M. J. Tilby, and C. A. Austin

Antimicrob. Agents Chemother. 1998 42: 1284-1287. Antibacterial Activities and Inhibitory Effects of Sitafloxacin (DU-6859a) and Its Optical Isomers against Type II Topoisomerases Takaaki Akasaka, Seiko Kurosaka, Yoko Uchida, Mayumi Tanaka, Kenichi Sato, and Isao Hayakawa

Mol. Pharmacol. 1998 53: 422-428. The Ortho-Quinone Metabolite of the Anticancer Drug Etoposide (VP-16) Is a Potent Inhibitor of the Topoisomerase II/DNA Cleavable ComplexTsvetan G. Gantchev and Darel J. Hunting

J. Biol. Chem 1998 273: 3635-3642. Casein Kinase II Stabilizes the Activity of Human Topoisomerase II in a Phosphorylation-independent MannerCharles Redwood, Sally L. Davies, Nicholas J. Wells, Andrew M. Fry, and Ian D. Hickson

Drug Metab. Dispos. 1998 26: 105-109. Identification and Characterization of in Vitro Metabolites of 2-[2-(Dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-dione (Azonafide)Craig A. Mayr, Salah M. Sami, William A. Remers, and Robert T. Dorr

J. Biol. Chem 1997 272: 32696-32703. The DNA Dependence of the ATPase Activity of Human DNA Topoisomerase IITimothy R. Hammonds and Anthony Maxwell

Genes & Dev. 1997 11: 3471-3481. DNA damage induces phosphorylation of the amino terminus of p53Janet D. Siliciano, Christine E. Canman, Yoichi Taya, Kazuyasu Sakaguchi, Ettore Appella, and Michael B. Kastan

J. Pharmacol. Exp. Ther. 1997 283: 1383-1388. Cell Cycle-Dependent Chronotoxicity of Irinotecan Hydrochloride in MiceShigehiro Ohdo, Tomoko Makinosumi, Takashi Ishizaki, Eiji Yukawa, Shun Higuchi, Shigeyuki Nakano, and Nobuya Ogawa

Mol. Pharmacol. 1997 52: 839-845. Mitindomide Is a Catalytic Inhibitor of DNA Topoisomerase II That Acts at the Bisdioxopiperazine Binding SiteBrian B. Hasinoff, Andrew M. Creighton, Hanna Kozlowska, Padmakumari Thampatty, William P. Allan, and Jack C. Yalowich

J. Biol. Chem 1997 272: 24631-24636. The Identification and Characterization of a G4-DNA Resolvase ActivityCindy Harrington, Yun Lan, and Steven A. Akman

J. Biol. Chem 1997 272: 10817-10822. The Condensation of Chromatin in Apoptotic Thymocytes Shows a Specific Structural ChangeCaterina Allera, Giuseppe Lazzarini, Eligio Patrone, Ingles Alberti, Paola Barboro, Paola Sanna, Antonella Melchiori, Silvio Parodi, and Cecilia Balbi

Blood 1997 89: 2480-2487. Possible Roles of an Adult T-Cell Leukemia (ATL)-Derived Factor/Thioredoxin in the Drug Resistance of ATL to Adriamycin Jingxin Wang, Masanobu Kobayashi, Keisuke Sakurada, Masahiro Imamura, Tetsuya Moriuchi, and Masuo Hosokawa

J. Biol. Chem 1997 272: 8731-8738. Topological Analysis of the Role of Homology in Flp-mediated Recombination Naiyer Azam, Julie E. Dixon, and Paul D. Sadowski

Mol. Pharmacol. 1997 51: 448-461. Copper-Dependent Oxidative and Topoisomerase II-Mediated DNA Cleavage by a Netropsin/4-(9-acridinylamino)methanesulfon-m-anisidide Combilexin Jean-Pierre Henichart, Michael J. Waring, Jean-Francois Riou, William A. Denny, and Christian Bailly

J. Histochem. Cytochem. 1997 45: 251-264. Detection of Human Topoisomerase II in Cell Lines and Tissues: Characterization of Five Novel Monoclonal Antibodies Udo Kellner, Hans-Juergen Heidebrecht, Pierre Rudolph, Harald Biersack, Friedrich Buck, Thomas Dakowski, Hans-Heinrich Wacker, Marcus Domanowski, Andre Seidel, Ole Westergaard, and Reza Parwaresch

Mol. Pharmacol. 1997 51: 269-276. Correlation between the Formation of Cleavable Complex with Topoisomerase I and Growth-Inhibitory Activity for Saintopin-Type Antibiotics Noboru Fujii, Yoshinori Yamashita, Tamio Mizukami, and Hirofumi Nakano

J. Cell Biol. 1997 136: 29-43. Chromosomes with Two Intact Axial Cores Are Induced by G2 Checkpoint Override: Evidence That DNA Decatenation Is not Required to Template the Chromosome Structure Paul R. Andreassen, Françoise B. Lacroix, and Robert L. Margolis

PNAS 1996 93: 14416-14421. Conversion of DNA gyrase into a conventional type II topoisomerase Sotirios C. Kampranis and Anthony Maxwell

J. Biol. Chem 1996 271: 1993-1997. Identification of a Nucleolin Binding Site in Human Topoisomerase I Ajit K. Bharti, Mark O. J. Olson, Donald W. Kufe, and Eric H. Rubin

Hanlin ao, Kuan-Chun Huang, Edith F. Yamasaki, Kenneth K. Chan, Lubna Chohan, and Robert M. Snapka. XK469, a selective topoisomerase II poison PNAS 1999 96: 12168-12173. [this is the first report of a specfic type II beta poison]

Yuji Takebayashi, Philippe Pourquier, Akira Yoshida, Glenda Kohlhagen, and Yves Pommier Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancer drug that selectively alkylates DNA in the minor groove PNAS 1999 96: 7196-7201

Cynthia M. Simbulan-Rosenthal, Bassem R. Haddad, Dean S. Rosenthal, Zoë Weaver, Allen Coleman, RuiBai Luo, Hannah M. Young, Zhao-Qi Wang, Thomas Ried, and Mark E. Smulson Chromosomal aberrations in PARP/ mice: Genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA PNAS 1999 96: 13191-13196

Céline Gobert, Andrzej Skladanowski, and Annette K. Larsen The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53 PNAS 1999 96: 10355-10360.

Uppoor G. Bhat, Pradip Raychaudhuri, and William T. Beck Functional interaction between human topoisomerase II and retinoblastoma protein PNAS 1999 96: 7859-7864.

Eduardo J. Martinez, Takashi Owa, Stuart L. Schreiber, and E. J. Corey Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743 PNAS 1999 96: 3496-3501.

Sotirios C. Kampranis and Anthony Maxwell Conversion of DNA gyrase into a conventional type II topoisomerase PNAS 1996 93: 14416-14421

Young Kwon, Beom Sic Shin, and In Kwon Chung The p53 tumor suppressor stimulates the catalytic activity of Human topoisomerase II alpha by enhancing the rate of ATP hydrolysis*Papers in Press: J. Biol. Chem. published April 7, 2000

Anton Tevelev and David G. Schatz Intermolecular V(D)J Recombination J. Biol. Chem. 2000 275: 8341-8348

Reiner Strick, Pamela L. Strissel, Susanne Borgers, Steve L. Smith, and Janet D. Rowley Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia PNAS published April 11, 2000, 10.1073/pnas.070061297

Carrie Walowsky, David J. Fitzhugh, Irene B. Castaño, Justina Y. Ju, Nikki A. Levin, and Michael F. Christman The Topoisomerase-related Function Gene TRF4 Affects Cellular Sensitivity to the Antitumor Agent Camptothecin J. Biol. Chem. 1999 274: 7302-7308

Ebba U. Kurz, Kelly B. Leader, David J. Kroll, Michael Clark, and Frank Gieseler Modulation of Human DNA Topoisomerase II Function by Interaction with 14-3-3 J. Biol. Chem. 2000 275: 13948-13954

Anton Tevelev and David G. Schatz Intermolecular V(D)J Recombination J. Biol. Chem. 2000 275: 8341-8348

Lothar Halmer, Birgit Vestner, and Claudia Gruss Involvement of Topoisomerases in the Initiation of Simian Virus 40 Minichromosome Replication J. Biol. Chem. 1998 273: 34792-34798

Eduardo J. Martinez, Takashi Owa, Stuart L. Schreiber, and E. J. Corey Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743 PNAS 96: 3496-3501

Q. Q. Pu and W. R. Bezwoda Induction of Alkylator (Melphalan) Resistance in HL60 Cells Is Accompanied by Increased Levels of Topoisomerase II Expression and Function
Mol Pharmacol 1999 56: 147-153.

You-Chan Kim, Junho Lee, and Hyeon-Sook Koo Functional characterization of Caenorhabditis elegans DNA topoisomerase III Nucl. Acids. Res. 2000 28: 2012-2017.

Ian Morrissey and John George Activities of Fluoroquinolones against Streptococcus pneumoniae Type II Topoisomerases Purified as Recombinant Proteins Antimicrob. Agents Chemother. 1999 43: 2579-2585.

Anne Y. C. Saiki, Linus L. Shen, Chih-Ming Chen, John Baranowski, and Claude G. Lerner

DNA Cleavage Activities of Staphylococcus aureus Gyrase and Topoisomerase IV Stimulated by Quinolones and 2-Pyridones Antimicrob. Agents Chemother. 1999 43: 1574-1577

Heather M. Smith and Andrew J. Grosovsky PolyADP-ribose-mediated regulation of p53 complexed with topoisomerase I following ionizing radiation Carcinogenesis 1999 20: 1439-1444

Kuan-Chun Huang, Hanlin Gao, Edith F. Yamasaki, Dale R. Grabowski, Shujun Liu, Linus L. Shen, Kenneth K. Chan, Ram Ganapathi, and Robert M. Snapka
Topoisomerase II Poisoning by ICRF-193
J. Biol. Chem., Nov 2001; 276: 44488 – 44494.

Thierry Viard, Valerie Lamour, Michel Duguet, and Claire Bouthier de la Tour
Hyperthermophilic Topoisomerase I from Thermotoga maritima. A VERY EFFICIENT ENZYME THAT FUNCTIONS INDEPENDENTLY OF ZINC BINDING
J. Biol. Chem., Nov 2001; 276: 46495 – 46503.

Kenichi Chikamori, Dale R. Grabowski, Michael Kinter, Belinda B. Willard, Satya Yadav, Ruedi H. Aebersold, Ronald M. Bukowski, Ian D. Hickson, Anni H. Andersen, Ram Ganapathi, and Mahrukh K. Ganapathi
Phosphorylation of Serine 1106 in the Catalytic Domain of Topoisomerase II Regulates Enzymatic Activity and Drug Sensitivity
J. Biol. Chem., Apr 2003; 278: 12696 – 12702.

Kevin L. Carrick and Michael D. Topal
Amino Acid Substitutions at Position 43 of NaeI Endonuclease. EVIDENCE FOR CHANGES IN NaeI STRUCTURE
J. Biol. Chem., Mar 2003; 278: 9733 – 9739.

Hiroshi Hiasa, Molly E. Shea, Christine M. Richardson, and Michael N. Gwynn
Staphylococcus aureus Gyrase-Quinolone-DNA Ternary Complexes Fail to Arrest Replication Fork Progression in Vitro. EFFECTS OF SALT ON THE DNA BINDING MODE AND THE CATALYTIC ACTIVITY OF S. AUREUS GYRASE
J. Biol. Chem., Feb 2003; 278: 8861 – 8868.

Monique C. A. Duyndam, Saskia T. M. Hulscher, Elsken van der Wall, Herbert M. Pinedo, and Epie Boven
Evidence for a Role of p38 Kinase in Hypoxia-inducible Factor 1-independent Induction of Vascular Endothelial Growth Factor Expression by Sodium Arsenite
J. Biol. Chem., Feb 2003; 278: 6885 – 6895

Isabelle Plo, Hélène Hernandez, Glenda Kohlhagen, Dominique Lautier, Yves Pommier, and Guy Laurent
Overexpression of the Atypical Protein Kinase C Reduces Topoisomerase II Catalytic Activity, Cleavable Complexes Formation, and Drug-induced Cytotoxicity in Monocytic U937 Leukemia Cells
J. Biol. Chem., Aug 2002; 277: 31407 – 31415.

Jeanie F. Kincer, Annette Uittenbogaard, James Dressman, Theresa M. Guerin, Maria Febbraio, Ling Guo, and Eric J. Smart
Hypercholesterolemia Promotes a CD36-dependent and Endothelial Nitric-oxide Synthase-mediated Vascular Dysfunction
J. Biol. Chem., Jun 2002; 277: 23525 – 23533.

Victor T. Solovyan, Zinayida A. Bezvenyuk, Antero Salminen, Caroline A. Austin, and Michael J. Courtney
The Role of Topoisomerase II in the Excision of DNA Loop Domains during Apoptosis
J. Biol. Chem., Jun 2002; 277: 21458 – 21467.

Valérie Lamour, Laurence Hoermann, Jean-Marc Jeltsch, Pierre Oudet, and Dino Moras
An Open Conformation of the Thermus thermophilus Gyrase B ATP-binding Domain
J. Biol. Chem., May 2002; 277: 18947 – 18953.

Yinghui Mao, Issac R. Mehl, and Mark T. Muller
Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status
PNAS 2002 99: 1235-1240; published online before print as 10.1073/pnas.022631899

Reiner Strick, Pamela L. Strissel, Susanne Borgers, Steve L. Smith, and Janet D. Rowley
From the Cover: Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia
PNAS 2000 97: 4790-4795;

Sunil J. Advani, Ralph R. Weichselbaum, and Bernard Roizman
Herpes simplex virus 1 activates cdc2 to recruit topoisomerase II for post-DNA synthesis expression of late genes
PNAS 2003 100: 4825-4830

Philippe Pourquier, Yuji Takebayashi, Yoshimasa Urasaki, Christopher Gioffre, Glenda Kohlhagen, and Yves Pommier
Induction of topoisomerase I cleavage complexes by 1–D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells
PNAS 2000; 97: 1885-1890.

Delineation of the domains required for physical and functional interaction of p14ARF with human topoisomerase I
Ayrault Olivier, Karayan Lucie, Riou Jean-François, Larsen Christian-Jacques, Séité Paule Oncogene 22, 1945 – 1954 (03 Apr 2003) Original Article

Induction of breast cancer resistance protein by the camptothecin derivative DX-8951f is associated with minor reduction of antitumour activity
A H van Hattum, I J Hoogsteen, H M M Schlüper, M Maliepaard, G L Scheffer, R J Scheper, G Kohlhagen, Y Pommier, H M Pinedo, E Boven
SUMMARY: DX-8951f (exatecan mesylate), a new water-soluble derivative of camptothecin, is currently being evaluated in phase II clinical trials. Resistance may be acquired when treating…
British Journal of Cancer87, 665 – 672 (09 Sep 2002) Experimental Therapeutics

CpG methylation is maintained in human cancer cells lacking DNMT1
Ina Rhee, Kam-Wing Jair, Ray-Whay Chiu Yen, Christoph Lengauer, James G. Herman, Kenneth W. Kinzler, Bert Vogelstein, Stephen B. Baylin, Kornel E. Schuebel
SUMMARY: Hypermethylation is associated with the silencing of tumour susceptibility genes in several forms of cancer; however, the mechanisms responsible for this aberrant methylation are…
Nature404, 1003 – 1007 (27 Apr 2000) Letters to Nature

The amino terminus targets the mixed lineage leukemia (MLL) protein to the nucleolus, nuclear matrix and mitotic chromosomal scaffolds
C Caslini, A Serna Alarcòn, J L Hess, R Tanaka, K G Murti, A Biondi
SUMMARY: The mixed-lineage leukemia gene (MLL) is associated with more than 25 chromosomal translocations involving band 11q23 in diverse subtypes of human acute leukemia. Conditional…
Leukemia14, 1898 – 1908 (23 Oct 2000)

Exposure to low concentrations of etoposide reduces the apoptotic capability of leukaemic cell lines
W M Liu, P R Oakley, S P Joel
SUMMARY: The use of topoisomerase inhibitors has been associated with the development of secondary malignancies, suggesting that these agents can induce DNA damage that may…
Leukemia16, 1705 – 1712 (01 Sep 2002)

DNA topoisomerase II is required for RNA polymerase II transcription on chromatin templates
Neelima Mondal, Jeffrey D. Parvin
SUMMARY: In the nucleus of the cell, core RNA polymerase II (pol II) is associated with a large complex called the pol II holoenzyme (holo-pol)….
Nature413, 435 – 438 (27 Sep 2001) Letters to Nature

Histone deacetylase interacts directly with DNA topoisomerase II
Shih-Chang Tsai, Nikola Valkov, Wen-Ming Yang, Jana Gump, Daniel Sullivan, Edward Seto
SUMMARY: Histone deacetylases (HDACs) modify nucleosomal histones, have a key role in the regulation of gene transcription, and may be involved in cell-cycle regulation, differentiation…
Nature Genetics26, 349 – 353 (01 Nov 2000) Letters

Human ARF protein interacts with Topoisomerase I and stimulates its activity
Lucie Karayan, Jean-François Riou, Paule Séité, Julien Migeon, Anne Cantereau, Christian-Jacques Larsen
SUMMARY: The ARF gene (p19ARF in mouse and p14ARF in man) has become a central actor of the cell cycle regulation process as it participates…
Oncogene19, 836 – 848 (16 Feb 2001) Original Paper

Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1
Barbara C Godthelp, Fré Artwert, Hans Joenje, Magorzata Z Zdzienicka
SUMMARY: Fanconi anemia is a hereditary cancer susceptibility disorder characterized at the cellular level by spontaneous chromosomal instability and specific hypersensitivity to DNA cross-linking agents…
Oncogene21, 5002 – 5005 (25 Jul 2002) Scientific Correspondence