HU-331 is a cannabinoid-based quinone with potential anticancer activity. It has anti-topo IIa activity as a catalytic inhibitor rather than a poison (such as etoposide).
Chemical Name: 3-hyroxy-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-2,5-cyclohexadiene-1,4-dione
Molecular Formula: C21H28O3
Molecular Weight: 328.5
HU-331 acts to inhibit the ATPase activity of the enzyme and has been shown to be effective in killing tumor cells. The drug may also influence redox associated action. Recent work has shown that HU-331 block catalytic action of topoisomerase II and the action is specific for human topo IIa and does not act on DNA gyrase from E. coli or on human topo I. The inhibitory action is redox dependent. TopoGEN provides this reagent as a control inhibitor of topoisomerase IIa and it is not recommended as a control for interfacial poisoning. HU-331 is somewhat aqueous soluble (up to 0.5mg/ml in 50% ethanol in PBS buffer). The drug is pre-tested and shown to inhibit relaxation, decatenation and DNA cleavage activity of human DNA topoisomerase IIa.
TG4200 contains 25 ul of 10mM solution of HU-331 in 100% DMSO (corresponding to 3.28mg/ml).
The liquid product is shipped on dry ice. Store at -20°C.
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