Ellipticine is a topoisomerase II poison that induces topo II dependent cleavages
Chemical Name: 5,11-Dimethyl-6H-Pyrido[4,3]Carbazole
Molecular Formula: C17H14N2
Molecular Weight: 246.31
TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase II. For in vitro cleavage detection, we recommend that the drug be tested over a wide range of uM concentrations; however, cleavages are strongly influenced by the amount of topoisomerase in the reaction as well as the type of assay being employed (SDSK+ vs. Radioactive End Labeled DNA vs. testing for plasmid cleavages). Note that large amounts of enzyme will be required to detect cleavage complex, compared to assays that measure catalytic activity.
TG4170 is supplied already suspended in DMSO at 10 mM (0.25 ml) and is ready for use. The drug is pre-tested and shown to induce topo cleavages using purified human topoisomerase from TopoGEN.
The liquid product is shipped on blue ice. Store at -20°C.
If you require additional information about this product, please contact us at: firstname.lastname@example.org
Additional Information & Media relating to Product