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Cell Context DNA Repair
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Product ID | Product Info | Description | Purchase |
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DR3000-HRHeLa-Sce |
This is a HeLa cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and genes) that affect or impact the process of HR DNA repair. The kit uses GFP as an in situ readout for the HR pathway. |
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DR3000-HRHeLa |
This is a cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and genes) that affect or impact the process of HR DNA repair. The kit uses GFP as an in vivo readout for the HR pathway and Crispr-CAS… Read more (+) This is a cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and genes) that affect or impact the process of HR DNA repair. The kit uses GFP as an in vivo readout for the HR pathway and Crispr-CAS gRNA plasmid that drives a […] Show less (-) |
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DR3000-HRSH-Sce |
DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR… Read more (+) DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR can be very beneficial for drug […] Show less (-) |
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DR3000-HR3T3-Sce |
This is a cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and genes) that affect or impact the process of HR DNA repair. The kit uses GFP as an in vivo readout for the HR pathway and a… Read more (+) This is a cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and genes) that affect or impact the process of HR DNA repair. The kit uses GFP as an in vivo readout for the HR pathway and a plasmid expression vector containing the […] Show less (-) |
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DR3000-HRCN1.4-Sce |
This is the first HR reporter that has been engineered into a neuronally derived mouse cell line model. The CN1.4 cell line is a clone derived from mouse embryonic day 13 neuronal cultures. The line was transformed using the temperature-sensitive SV-40 Large T-antigen. The cell line expresses… Read more (+) This is the first HR reporter that has been engineered into a neuronally derived mouse cell line model. The CN1.4 cell line is a clone derived from mouse embryonic day 13 neuronal cultures. The line was transformed using the temperature-sensitive SV-40 Large T-antigen. The cell line expresses numerous neuronal markers, including neurofilaments, glutamic acid decarboxylase […] Show less (-) |
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DR3000 |
DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. The process has two key requirements as well: a homologous sequence, usually available after DNA replication… Read more (+) DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. The process has two key requirements as well: a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase. […] Show less (-) |
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DR5001-HNHeLa-Sce |
This is a HeLa cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and other genes) that affect or impact NHEJ repair. The kit uses GFP as an in situ readout for NHEJ activity in a cell context. |
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DR5000-HNSH-Sce |
This is a cell-based reporter kit that is hosted by a human neuroblastoma cell line (SH-SY5Y) that can grow continuously in vitro and will terminally differentiate. This provides the opportunity of analyzing NHEJ in growing or terminally differentiated cells in a neuronal lineage. |
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DR5000-HN3T3-Sce |
This is a Mouse 3T3 cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and other genes) that affect or impact NHEJ repair. The kit uses GFP as an in situ readout for NHEJ activity in a cell context… Read more (+) This is a Mouse 3T3 cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and other genes) that affect or impact NHEJ repair. The kit uses GFP as an in situ readout for NHEJ activity in a cell context. Show less (-) |
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DR5000-HNCN1.4 |
TopoGEN scientists have created a novel, cell based kit to follow NHEJ by simply assaying for the presence of GFP positive cells (Fig 1). DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. Homologous recombination (HR) is a minor pathway but very… Read more (+) TopoGEN scientists have created a novel, cell based kit to follow NHEJ by simply assaying for the presence of GFP positive cells (Fig 1). DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. Homologous recombination (HR) is a minor pathway but very important in protecting cells from genotoxicity. […] Show less (-) |
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DR5000 |
Custom Cell Based Screening Kit for NHEJ contains reagents necessary to create a complete NHEJ reporter system in any animal cell line. It includes the NHEJ-GFP reporter with a selectable marker and a DS DNA cleavage nuclease to initiate DNA repair. |
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DR3050 |
This is a custom cell-based reporter system designed to allow researchers to study homologous recombination (HR) in a cell line of their choosing. The kit uses GFP as an in vivo readout for the HR pathway and includes proper controls to set the system up in your own lab. Because… Read more (+) This is a custom cell-based reporter system designed to allow researchers to study homologous recombination (HR) in a cell line of their choosing. The kit uses GFP as an in vivo readout for the HR pathway and includes proper controls to set the system up in your own lab. Because this system relies on pools of cells that take up reporter and effector genes (HR-GFP and I-Sce1 respectively) the system can be ‘hosted’ in any cell of interest. The only limit is transfection efficiency. There is no need to engage in time consuming and labor intensive cell line cloning and development...you simply transfect and let the system proceed through HR over a 48h period. Easy! Show less (-) |
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