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Cell Context DNA Repair

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DR3000-HRHeLa-Sce
This is a HeLa cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and genes) that affect or impact the process of HR DNA repair. The kit uses GFP as an in situ readout for the HR pathway.  
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DR3000-HRHeLa
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication…
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DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase.  […]
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DR3000-HRSH-Sce
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR…
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DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR can be very beneficial for drug […]
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DR3000-HR3T3-Sce
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication…
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DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase.  […]
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DR3000-HRCN1.4-Sce
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR…
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DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR can be very beneficial for drug […]
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DR3000
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication…
Read more (+)
DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity.  The process has two key requirements as well:  a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase.  […]
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DR5001-HNHeLa-Sce
This is a HeLa cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and other genes) that affect or impact NHEJ repair. The kit uses GFP as an in situ readout for NHEJ activity in a cell context.
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DR5000-HNSH-Sce
This is a cell-based reporter kit that is hosted by a human neuroblastoma cell line (SH-SY5Y) that can grow continuously in vitro and will terminally differentiate.  This provides the opportunity of analyzing NHEJ in growing or terminally differentiated cells in a neuronal lineage.
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DR5000-HN3T3-Sce
This is a Mouse 3T3 cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and other genes) that affect or impact NHEJ repair. The kit uses GFP as an in situ readout for NHEJ activity in a cell context…
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This is a Mouse 3T3 cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and other genes) that affect or impact NHEJ repair. The kit uses GFP as an in situ readout for NHEJ activity in a cell context.      
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DR5000-HNCN1.4
TopoGEN scientists have created a novel, cell based kit to follow NHEJ by simply assaying for the presence of GFP positive cells (Fig 1). DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  Homologous recombination (HR) is a minor pathway but very…
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TopoGEN scientists have created a novel, cell based kit to follow NHEJ by simply assaying for the presence of GFP positive cells (Fig 1). DNA Repair pathways in animal cells can be divided into two main categories:  HR and NHEJ.  Homologous recombination (HR) is a minor pathway but very important in protecting cells from genotoxicity.  […]
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DR5000
Custom Cell Based Screening Kit for NHEJ contains reagents necessary to create a complete NHEJ reporter system in any animal cell line.  It includes the NHEJ-GFP reporter with a selectable marker and a DS DNA cleavage nuclease to initiate DNA repair.
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DR3050
This is a custom cell-based reporter system designed to allow researchers to study HR in a cell line of their choosing. The kit uses GFP as an in vivo readout for the HR pathway and includes proper controls to set the system up in your own lab. Because this system…
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This is a custom cell-based reporter system designed to allow researchers to study HR in a cell line of their choosing. The kit uses GFP as an in vivo readout for the HR pathway and includes proper controls to set the system up in your own lab. Because this system relies on pools of cells that take up reporter and effector genes (HR-GFP and I-Sce1 respectively) the system can be ‘hosted’ in any cell of interest.  The only limit is transfection efficiency.  There is no need to engage in time consuming and labor intensive cell line cloning and development...you simply transfect and let the system proceed through HR over a 48h period.  Easy!
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