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Topo Related Drugs

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TG4100
Hycamtin (topotecan hydrochloride) is a semi-synthetic derivative of camptothecin and is an anti-tumor drug that targets topo I and is a topo I poison (induces cleavage complexes).
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TG4110
Camptothecin is a topo I poison that both inhibits enzyme activity and stabilizes formation of topo I cleavage complexes (Hsiang et al J. Biol. Chem. 260:14873-14878, 1985).  TopoGEN provides this reagent as a control inhibitor/poison of topoisomerase I.  For in vitro cleavage detection, we recommend that the drug…
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Camptothecin is a topo I poison that both inhibits enzyme activity and stabilizes formation of topo I cleavage complexes (Hsiang et al J. Biol. Chem. 260:14873-14878, 1985).  TopoGEN provides this reagent as a control inhibitor/poison of topoisomerase I.  For in vitro cleavage detection, we recommend that the drug be tested in the range 100 uM; […]
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TG4102
20(S)camptothecin has shown promising activity against a range of tumour types.  This CPT derivative causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single and double strand breaks.  TopoGEN provides this reagent as a control poison/inhibitor…
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20(S)camptothecin has shown promising activity against a range of tumour types.  This CPT derivative causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single and double strand breaks.  TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase I.  For in vitro cleavage […]
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TG4103
10-Hydroxy Camptothecin has shown promising activity against a range of tumour types. This CPT derivative causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single and double strand breaks. TopoGEN provides this reagent as a control poison/inhibitor of…
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10-Hydroxy Camptothecin has shown promising activity against a range of tumour types. This CPT derivative causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single and double strand breaks. TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase I. For in vitro […]
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TG4104
9-Amino-20-(R,S)-camptothecin (also known as 9-amino campthecin) is an analogue of camptothecin.  Like other CPT congeners, it shows some promising activity against a range of tumor types.  This compound causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA…
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9-Amino-20-(R,S)-camptothecin (also known as 9-amino campthecin) is an analogue of camptothecin.  Like other CPT congeners, it shows some promising activity against a range of tumor types.  This compound causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single and double strand breaks.  TopoGEN […]
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TG4120
TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase II.  For in vitro cleavage detection, we recommend that the drug be tested over a wide range of uM concentrations; however, cleavages are strongly influenced by the amount of topoisomerase in the reaction as well as the type of…
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TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase II.  For in vitro cleavage detection, we recommend that the drug be tested over a wide range of uM concentrations; however, cleavages are strongly influenced by the amount of topoisomerase in the reaction as well as the type of assay being employed (SDSK+ vs. Radioactive […]
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TG4130
TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase II.  For in vitro cleavage detection, we recommend that the drug be tested over a wide range of uM concentrations; however, cleavages are strongly influenced by the amount of topoisomerase in the reaction as well as the type of…
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TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase II.  For in vitro cleavage detection, we recommend that the drug be tested over a wide range of uM concentrations; however, cleavages are strongly influenced by the amount of topoisomerase in the reaction as well as the type of assay being employed (SDSK+ vs. Radioactive […]
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TG4140
TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase II.  For in vitro cleavage detection, we recommend that the drug be tested over a wide range of uM concentrations; however, cleavages are strongly influenced by the amount of topoisomerase in the reaction as well as the type of…
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TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase II.  For in vitro cleavage detection, we recommend that the drug be tested over a wide range of uM concentrations; however, cleavages are strongly influenced by the amount of topoisomerase in the reaction as well as the type of assay being employed (SDSK+ vs. Radioactive […]
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TG4150
TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase II.  For in vitro cleavage detection, we recommend that the drug be tested over a wide range of uM concentrations; however, cleavages are strongly influenced by the amount of topoisomerase in the reaction as well as the type of…
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TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase II.  For in vitro cleavage detection, we recommend that the drug be tested over a wide range of uM concentrations; however, cleavages are strongly influenced by the amount of topoisomerase in the reaction as well as the type of assay being employed (SDSK+ vs. Radioactive […]
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TG4160
Genistein is an isoflavone and an inhibitor of tyrosine protein kinases.  It has been reported to induce topo II dependent cleavages (Biochem. Pharmacol. 39:737-740 [1990]).  TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase II (Note, Genistein may also inhibit topoisomerase I.)  For in vitro cleavage…
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Genistein is an isoflavone and an inhibitor of tyrosine protein kinases.  It has been reported to induce topo II dependent cleavages (Biochem. Pharmacol. 39:737-740 [1990]).  TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase II (Note, Genistein may also inhibit topoisomerase I.)  For in vitro cleavage detection, we recom- mend that the drug be […]
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TG4170
Ellipticine is a topoisomerase II poison that induces topo II dependent cleavages
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TG4200
HU-331 is a cannabinoid-based quinone with potential anticancer activity.  It has anti-topo IIa activity as a catalytic inhibitor rather than a poison (such as etoposide).    
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TG4180
A control poison/inhibitor of DNA Gyrase and Topo IV.  This is also included in the Topo IV/Gyrase Drug Screening Kits.
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TG4101
Irinotecan (CPT-11) Description Irinotecan (also known as CPT-11) is a water soluble, semi-synthetic analogue of 20(S)camptothecin (CPT) with promising activity against a range of tumour types.  Irinotecan causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single…
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Irinotecan (CPT-11) Description Irinotecan (also known as CPT-11) is a water soluble, semi-synthetic analogue of 20(S)camptothecin (CPT) with promising activity against a range of tumour types.  Irinotecan causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single and double strand breaks. [Clin Exp […]
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