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Drug Screening Kits
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Product ID | Product Info | Description | Purchase |
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TG1018 |
The Topo I Drug Kit is designed to allow the investigator to quickly identify novel inhibitors of Human Top1. The kit will allow detection of novel compounds that either stabilize the nicked intermediate or otherwise inhibit catalytic activity of topoisomerase I. |
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TG1009 |
This is a cleavage based detection kit that will reveal whether a particular agent either antagonizes the action of topo II or affects the cleavage/religation cycle. Reactions are assembled in microcentrifuge tubes using reagents supplied in the kit (buffer, DNA, control inhibitor). |
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TG1019 |
This kDNA based Topo II Drug Screening Kit is designed to identify agents that target type II topoisomerases acting as catalytic inhibitors, primarily; however, poisons can also be detected with this kit. |
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TG2001GKIT |
This kit contains purified bacterial (E. coli) DNA Gyrase purified to homogeneity (>98% based on SDS-PAGE). The Gyrase is prepared from overexpressing strains and is supplied as purified holoenzyme in an A2B2 complex. The enzyme is supplied at the unit concentration given on the quality control data provided… Read more (+) This kit contains purified bacterial (E. coli) DNA Gyrase purified to homogeneity (>98% based on SDS-PAGE). The Gyrase is prepared from overexpressing strains and is supplied as purified holoenzyme in an A2B2 complex. The enzyme is supplied at the unit concentration given on the quality control data provided with the kit. It is also stored […] Show less (-) |
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TG1017 |
This kit is designed to allow the customer to screen for agents (drugs, natural products, small molecules, synthetics) that block the catalytic activity of human topoisomerase I (topo I). The use of high stoichiometric ratios of topo I:DNA induces cleavage complexes without the need to use topo I poisons… Read more (+) This kit is designed to allow the customer to screen for agents (drugs, natural products, small molecules, synthetics) that block the catalytic activity of human topoisomerase I (topo I). The use of high stoichiometric ratios of topo I:DNA induces cleavage complexes without the need to use topo I poisons (camptothecin) which facilitates detection of catalytic […] Show less (-) |
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TG1007 |
The Topoisomerase IV Drug Screening Kit contains reagents necessary to identify compounds that affect enzyme activity. Note that kits with a catalog number denoted -A will include E. coli topoisomerase IV enyzme. |
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