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Drug Screening Kits

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TG1018
The Topo I Drug Kit introduces transient nicks in DNA at specific sites.  Detection of these transient DNA nicks requires trapping the enzyme on DNA in a nicked intermediate complex using protein denaturants. The resulting covalent DNA/topo I complexes contain nicked open circular DNA which can be detected by…
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The Topo I Drug Kit introduces transient nicks in DNA at specific sites.  Detection of these transient DNA nicks requires trapping the enzyme on DNA in a nicked intermediate complex using protein denaturants. The resulting covalent DNA/topo I complexes contain nicked open circular DNA which can be detected by agarose gel electrophoresis (with ethidium bromide).  […]
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TG1009
Topo II inhibitors have been shown to possess effective antibacterial, antiviral and anticancer activity. Identification of topo II inhibitors and antagonists requires tractable biochemical assays employing purified enzyme.  The Topoisomerase II Drug Screening Kit contains the reagents necessary to screen for agents that affect enzymatic activity.  To allow…
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Topo II inhibitors have been shown to possess effective antibacterial, antiviral and anticancer activity. Identification of topo II inhibitors and antagonists requires tractable biochemical assays employing purified enzyme.  The Topoisomerase II Drug Screening Kit contains the reagents necessary to screen for agents that affect enzymatic activity.  To allow the customer maximum flexibility, some kits include […]
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TG1019
Topo II inhibitors have been shown to possess effective antibacterial, antiviral and anticancer activity. Identification of topo II inhibitors and antagonists requires tractable biochemical assays employing purified enzyme.  The Topoisomerase II Drug Screening Kit contains the reagents necessary to screen for agents that affect enzymatic activity.  To allow…
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Topo II inhibitors have been shown to possess effective antibacterial, antiviral and anticancer activity. Identification of topo II inhibitors and antagonists requires tractable biochemical assays employing purified enzyme.  The Topoisomerase II Drug Screening Kit contains the reagents necessary to screen for agents that affect enzymatic activity.  To allow the customer maximum flexibility, some kits include […]
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TG2001GKIT
This kit contains purified bacterial (E. coli) DNA Gyrase  purified to homogeneity (>98% based on SDS-PAGE). The Gyrase is prepared from overexpressing strains and is supplied as purified holoenzyme in an A2B2 complex.  The enzyme is supplied at the unit concentration given on the quality control data provided…
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This kit contains purified bacterial (E. coli) DNA Gyrase  purified to homogeneity (>98% based on SDS-PAGE). The Gyrase is prepared from overexpressing strains and is supplied as purified holoenzyme in an A2B2 complex.  The enzyme is supplied at the unit concentration given on the quality control data provided with the kit.  It is also stored […]
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TG1017
This kit is designed to allow the customer to screen for agents (drugs, natural products, small molecules, synthetics) that block the catalytic activity of human topoisomerase I (topo I).  The use of high stoichiometric ratios of topo I:DNA induces cleavage complexes without the need to use topo I poisons…
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This kit is designed to allow the customer to screen for agents (drugs, natural products, small molecules, synthetics) that block the catalytic activity of human topoisomerase I (topo I).  The use of high stoichiometric ratios of topo I:DNA induces cleavage complexes without the need to use topo I poisons (camptothecin) which facilitates detection of catalytic […]
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TG1007
The Topoisomerase IV Drug Screening Kit contains reagents necessary to identify compounds that affect enzyme activity.  Note that kits with a catalog number denoted -A will include E. coli topoisomerase IV enyzme.  This kit will allow detection of two kinds of topoisomerase inhibitors: those that stimulate formation of…
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The Topoisomerase IV Drug Screening Kit contains reagents necessary to identify compounds that affect enzyme activity.  Note that kits with a catalog number denoted -A will include E. coli topoisomerase IV enyzme.  This kit will allow detection of two kinds of topoisomerase inhibitors: those that stimulate formation of cleavable complexes and those that antagonize topoisomerase […]
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