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TG4200
HU-331 is a cannabinoid-based quinone with potential anticancer activity.  It has anti-topo IIa activity as a catalytic inhibitor rather than a poison (such as etoposide).    
TG4101
Irinotecan (CPT-11) Description Irinotecan (also known as CPT-11) is a water soluble, semi-synthetic analogue of 20(S)camptothecin (CPT) with promising activity against a range of tumour types.  Irinotecan causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single…
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Irinotecan (CPT-11) Description Irinotecan (also known as CPT-11) is a water soluble, semi-synthetic analogue of 20(S)camptothecin (CPT) with promising activity against a range of tumour types.  Irinotecan causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single and double strand breaks. [Clin Exp […]
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TG4103
10-Hydroxy Camptothecin has shown promising activity against a range of tumour types. This CPT derivative causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single and double strand breaks. TopoGEN provides this reagent as a control poison/inhibitor of…
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10-Hydroxy Camptothecin has shown promising activity against a range of tumour types. This CPT derivative causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I (topo I) and double-stranded DNA, leading to single and double strand breaks. TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase I. For in vitro […]
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TG4140
TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase II.  For in vitro cleavage detection, we recommend that the drug be tested over a wide range of uM concentrations; however, cleavages are strongly influenced by the amount of topoisomerase in the reaction as well as the type of…
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TopoGEN provides this reagent as a control poison/inhibitor of topoisomerase II.  For in vitro cleavage detection, we recommend that the drug be tested over a wide range of uM concentrations; however, cleavages are strongly influenced by the amount of topoisomerase in the reaction as well as the type of assay being employed (SDSK+ vs. Radioactive […]
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TG2038
Tyrosyl-DNA phosphodiesterase-2  (TDP2) functions to remove trapped topoisomerase II/DNA complexes by processing 5′- blocking protein (topo II) at the site of the DNA break (Fig 1).  Assaying this activity can be difficult, requiring labeled oligos and isotopes or complicated detections that are hard to set up.  In many…
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Tyrosyl-DNA phosphodiesterase-2  (TDP2) functions to remove trapped topoisomerase II/DNA complexes by processing 5′- blocking protein (topo II) at the site of the DNA break (Fig 1).  Assaying this activity can be difficult, requiring labeled oligos and isotopes or complicated detections that are hard to set up.  In many cases, these assays are largely derivative from […]
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TG1005
Tyrosyl-DNA phosphodiesterase-2  (TDP2) functions to remove trapped topoisomerase II/DNA complexes by processing 5′- blocking protein (topo II) at the site of the DNA break (Fig 1). In terms of physiological relevance, there appear to be multiple roles for TDP2, well beyond the repair of type II topoisomerase damage and subsequent…
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Tyrosyl-DNA phosphodiesterase-2  (TDP2) functions to remove trapped topoisomerase II/DNA complexes by processing 5′- blocking protein (topo II) at the site of the DNA break (Fig 1). In terms of physiological relevance, there appear to be multiple roles for TDP2, well beyond the repair of type II topoisomerase damage and subsequent DNA repair.  This is quite […]
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TG2003H
Tyrosyl-DNA phosphodiesterase-2  (TDP2) functions to remove trapped topoisomerase II/DNA complexes by processing 5′- blocking protein (topo II) at the site of the DNA break (Fig 1). In terms of physiological relevance, there appear to be multiple roles for TDP2, well beyond the repair of type II topoisomerase damage and subsequent…
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Tyrosyl-DNA phosphodiesterase-2  (TDP2) functions to remove trapped topoisomerase II/DNA complexes by processing 5′- blocking protein (topo II) at the site of the DNA break (Fig 1). In terms of physiological relevance, there appear to be multiple roles for TDP2, well beyond the repair of type II topoisomerase damage and subsequent DNA repair.  This is quite […]
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