our kits are well controlled, fully documented kits for topoisomerase projects & for interrogating dna repair pathway events
kits For Cancer Research & Drug Discovery
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Product ID | Product Info | Description | Purchase |
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DR3000-HRHeLa-Sce |
This is a HeLa cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and genes) that affect or impact the process of HR DNA repair. The kit uses GFP as an in situ readout for the HR pathway. |
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DR3000-HRHeLa |
DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. The process has two key requirements as well: a homologous sequence, usually available after DNA replication… Read more (+) DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. The process has two key requirements as well: a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase. […] Show less (-) |
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DR3000-HRSH-Sce |
DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR… Read more (+) DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR can be very beneficial for drug […] Show less (-) |
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DR3000-HR3T3-Sce |
DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. The process has two key requirements as well: a homologous sequence, usually available after DNA replication… Read more (+) DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. The process has two key requirements as well: a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase. […] Show less (-) |
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DR3000-HRCN1.4-Sce |
DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR… Read more (+) DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR can be very beneficial for drug […] Show less (-) |
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DR3000 |
DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. The process has two key requirements as well: a homologous sequence, usually available after DNA replication… Read more (+) DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. The process has two key requirements as well: a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase. […] Show less (-) |
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TG1001 |
This kit is designed to allow quick and specific assays for eukaryotic type II DNA topoisomerases. This kit facilitates the purification and characterization of type II enzymes and contains all reagents necessary for routine assays of type II topoisomerases. The assay is based upon decatentation of kinetoplast DNA (kDNA) and… Read more (+) This kit is designed to allow quick and specific assays for eukaryotic type II DNA topoisomerases. This kit facilitates the purification and characterization of type II enzymes and contains all reagents necessary for routine assays of type II topoisomerases. The assay is based upon decatentation of kinetoplast DNA (kDNA) and because it is specific for […] Show less (-) |
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TG1018 |
The Topo I Drug Kit is designed to allow the investigator to quickly identify novel inhibitors of Human Top1. The kit will allow detection of novel compounds that either stabilize the nicked intermediate or otherwise inhibit catalytic activity of topoisomerase I. |
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TG1015 |
The Human Topoisomerase I Assay kit contains reagents for routine detection of Top1 activity. DNA markers (included) allow unequivocal detection of the enzyme. The assay is specific for topoisomerase I; (eukaryotic type II topoisomerases require MgCl2 and ATP). The standard topo I assay kit is supplied with EDTA containing reaction… Read more (+) The Human Topoisomerase I Assay kit contains reagents for routine detection of Top1 activity. DNA markers (included) allow unequivocal detection of the enzyme. The assay is specific for topoisomerase I; (eukaryotic type II topoisomerases require MgCl2 and ATP). The standard topo I assay kit is supplied with EDTA containing reaction buffer (minus Mg++) in order […] Show less (-) |
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DR5001-HNHeLa-Sce |
DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. NHEJ is the major repair pathway in all animal cells and operates continuously during the entire… Read more (+) DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. NHEJ is the major repair pathway in all animal cells and operates continuously during the entire cell cycle. NHEJ is both error prone […] Show less (-) |
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TG1009 |
Topo II inhibitors have been shown to possess effective antibacterial, antiviral and anticancer activity. Identification of topo II inhibitors and antagonists requires tractable biochemical assays employing purified enzyme. The Topoisomerase II Drug Screening Kit contains the reagents necessary to screen for agents that affect enzymatic activity. To allow… Read more (+) Topo II inhibitors have been shown to possess effective antibacterial, antiviral and anticancer activity. Identification of topo II inhibitors and antagonists requires tractable biochemical assays employing purified enzyme. The Topoisomerase II Drug Screening Kit contains the reagents necessary to screen for agents that affect enzymatic activity. To allow the customer maximum flexibility, some kits include […] Show less (-) |
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TG1030 |
This assay kit contains all the reagents for cytolocalization of Human Top2a using immunofluorescence. The system is optimized for use with FITC or Rhodamine labeled secondary antibody with adherent cells. The method may work with other cells besides human. Mouse, rat and monkey cells will cross react with… Read more (+) This assay kit contains all the reagents for cytolocalization of Human Top2a using immunofluorescence. The system is optimized for use with FITC or Rhodamine labeled secondary antibody with adherent cells. The method may work with other cells besides human. Mouse, rat and monkey cells will cross react with topo II antibody. The antibody is specific […] Show less (-) |
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TG1003 |
The Kit is designed to allow quick and specific detection of DNA gyrase. This kit facilitates the purification and characterization of type II topoisomerase enzymes (DNA Gyrase) and contains all reagents necessary for routine assays of type II enzymes that either have or do not have the ability to supercoil… Read more (+) The Kit is designed to allow quick and specific detection of DNA gyrase. This kit facilitates the purification and characterization of type II topoisomerase enzymes (DNA Gyrase) and contains all reagents necessary for routine assays of type II enzymes that either have or do not have the ability to supercoil. Show less (-) |
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DR5000-HNSH-Sce |
DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. NHEJ is the major repair pathway in all animal cells and operates continuously during the entire… Read more (+) DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. NHEJ is the major repair pathway in all animal cells and operates continuously during the entire cell cycle. NHEJ is both error prone […] Show less (-) |
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TG1019 |
This kDNA based Topo II Drug Screening Kit is designed to identify agents that target type II topoisomerases acting as catalytic inhibitors, primarily; however, poisons can also be detected with this kit. |
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When you become our customer, we become your partner in research. We review your data and offer valuable input. Feel free to contact us for further information about how we can assist your topoisomerase research endeavors.