our kits are well controlled, fully documented kits for topoisomerase projects & for interrogating dna repair pathway events
kits For Cancer Research & Drug Discovery
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Product ID | Product Info | Description | Purchase |
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DR3000-HRHeLa-Sce |
This is a HeLa cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and genes) that affect or impact the process of HR DNA repair. The kit uses GFP as an in situ readout for the HR pathway. |
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DR3000-HRHeLa |
DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. The process has two key requirements as well: a homologous sequence, usually available after DNA replication… Read more (+) DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. The process has two key requirements as well: a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase. […] Show less (-) |
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DR3000-HRSH-Sce |
DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR… Read more (+) DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR can be very beneficial for drug […] Show less (-) |
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DR3000-HR3T3-Sce |
DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. The process has two key requirements as well: a homologous sequence, usually available after DNA replication… Read more (+) DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. The process has two key requirements as well: a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase. […] Show less (-) |
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DR3000-HRCN1.4-Sce |
DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR… Read more (+) DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. HR needs a homologous sequence and is limited to S-phase. A specific reporter based assay for HR can be very beneficial for drug […] Show less (-) |
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DR3000 |
DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. The process has two key requirements as well: a homologous sequence, usually available after DNA replication… Read more (+) DNA Repair pathways in animal cells can be divided into two main categories: HR and NHEJ. HR or homologous recombination is a minor pathway but very important in protecting cells from genotoxicity. The process has two key requirements as well: a homologous sequence, usually available after DNA replication when the genome is 4N, and S-phase. […] Show less (-) |
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TG1001 |
This kit is designed to allow quick and specific assays for any type II topoisomerase, either eu- or prokaryotic. This kit facilitates the purification and characterization of type II enzymes and contains all reagents necessary for routine assays of Topoisomerase II. |
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TG1018 |
The Topo I Drug Kit is designed to allow the investigator to quickly identify novel inhibitors of Human Top1. The kit will allow detection of novel compounds that either stabilize the nicked intermediate or otherwise inhibit catalytic activity of topoisomerase I. |
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TG1015 |
The Human Topoisomerase I Assay kit contains reagents for routine detection of Top1 activity. DNA markers (included) allow unequivocal detection of the enzyme. The assay is specific for topoisomerase I; (eukaryotic type II topoisomerases require MgCl2 and ATP). The standard topo I assay kit is supplied with EDTA containing reaction… Read more (+) The Human Topoisomerase I Assay kit contains reagents for routine detection of Top1 activity. DNA markers (included) allow unequivocal detection of the enzyme. The assay is specific for topoisomerase I; (eukaryotic type II topoisomerases require MgCl2 and ATP). The standard topo I assay kit is supplied with EDTA containing reaction buffer (minus Mg++) in order […] Show less (-) |
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DR5001-HNHeLa-Sce |
This is a HeLa cell-based reporter kit designed to allow the customer to screen or identify agents (drugs, natural products, small molecules, synthetics, miRNAs, and other genes) that affect or impact NHEJ repair. The kit uses GFP as an in situ readout for NHEJ activity in a cell context. |
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TG1009 |
This is a cleavage based detection kit that will reveal whether a particular agent either antagonizes the action of topo II or affects the cleavage/religation cycle. Reactions are assembled in microcentrifuge tubes using reagents supplied in the kit (buffer, DNA, control inhibitor). |
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TG1030 |
This assay kit contains all the reagents for cytolocalization of Human Top2a using immunofluorescence. The system is optimized for use with FITC or Rhodamine labeled secondary antibody with adherent cells. The method may work with other cells besides human. Mouse, rat and monkey cells will cross react with… Read more (+) This assay kit contains all the reagents for cytolocalization of Human Top2a using immunofluorescence. The system is optimized for use with FITC or Rhodamine labeled secondary antibody with adherent cells. The method may work with other cells besides human. Mouse, rat and monkey cells will cross react with topo II antibody. The antibody is specific […] Show less (-) |
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TG1003 |
The Kit is designed to allow quick and specific detection of DNA gyrase. This kit facilitates the purification and characterization of type II topoisomerase enzymes (DNA Gyrase) and contains all reagents necessary for routine assays of type II enzymes that either have or do not have the ability to supercoil… Read more (+) The Kit is designed to allow quick and specific detection of DNA gyrase. This kit facilitates the purification and characterization of type II topoisomerase enzymes (DNA Gyrase) and contains all reagents necessary for routine assays of type II enzymes that either have or do not have the ability to supercoil. Show less (-) |
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DR5000-HNSH-Sce |
This is a cell-based reporter kit that is hosted by a human neuroblastoma cell line (SH-SY5Y) that can grow continuously in vitro and will terminally differentiate. This provides the opportunity of analyzing NHEJ in growing or terminally differentiated cells in a neuronal lineage. |
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TG1019 |
This kDNA based Topo II Drug Screening Kit is designed to identify agents that target type II topoisomerases acting as catalytic inhibitors, primarily; however, poisons can also be detected with this kit. |
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When you become our customer, we become your partner in research. We review your data and offer valuable input. Feel free to contact us for further information about how we can assist your topoisomerase research endeavors.