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TPD I, II Products
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PRODUCT ID | Product Info | Description | Purchase |
|---|---|---|---|
TG2004H |
TopoGEN provides purified Human Tyrosyl DNA Phosphodiesterase (Tdp1) purified to homogeneity to a single 68 kDa band on SDS-PAGE. Tdp1 is catalytically active and will remove a terminal 3’ phosphotyrosyl group from a specifically designed oligo target site (oligo-Tyr). Additionally, TopoGEN scientists have demonstrated that Tdp1 will release… Show more (+) TopoGEN provides purified Human Tyrosyl DNA Phosphodiesterase (Tdp1) purified to homogeneity to a single 68 kDa band on SDS-PAGE. Tdp1 is catalytically active and will remove a terminal 3’ phosphotyrosyl group from a specifically designed oligo target site (oligo-Tyr). Additionally, TopoGEN scientists have demonstrated that Tdp1 will release topo I covalently attached to genomic DNA […] Show less (-) |
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TG2003H |
Tyrosyl-DNA phosphodiesterase-2 (TDP2) functions to remove trapped topoisomerase II/DNA complexes by processing 5′- blocking protein (topo II) at the site of the DNA break (Fig 1). In terms of physiological relevance, there appear to be multiple roles for TDP2, well beyond the repair of type II topoisomerase damage and subsequent… Show more (+) Tyrosyl-DNA phosphodiesterase-2 (TDP2) functions to remove trapped topoisomerase II/DNA complexes by processing 5′- blocking protein (topo II) at the site of the DNA break (Fig 1). In terms of physiological relevance, there appear to be multiple roles for TDP2, well beyond the repair of type II topoisomerase damage and subsequent DNA repair. This is quite […] Show less (-) |
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TG1005 |
Tyrosyl-DNA phosphodiesterase-2 (TDP2) functions to remove trapped topoisomerase II/DNA complexes by processing 5′- blocking protein (topo II) at the site of the DNA break (Fig 1). In terms of physiological relevance, there appear to be multiple roles for TDP2, well beyond the repair of type II topoisomerase damage and subsequent… Show more (+) Tyrosyl-DNA phosphodiesterase-2 (TDP2) functions to remove trapped topoisomerase II/DNA complexes by processing 5′- blocking protein (topo II) at the site of the DNA break (Fig 1). In terms of physiological relevance, there appear to be multiple roles for TDP2, well beyond the repair of type II topoisomerase damage and subsequent DNA repair. This is quite […] Show less (-) |
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TG2016 |
A rabbit polyclonal antibody was prepared against the native Tdp1 protein. The purity was greater than 99% as determined by SDS-PAGE. The antibody is in solution (PBS) at 2.5 unit/ul (see definitions of unit below). This antibody is ideal for Western blotting applications or immunoflourescent (IF)… Show more (+) A rabbit polyclonal antibody was prepared against the native Tdp1 protein. The purity was greater than 99% as determined by SDS-PAGE. The antibody is in solution (PBS) at 2.5 unit/ul (see definitions of unit below). This antibody is ideal for Western blotting applications or immunoflourescent (IF) studies on the cytological localization. The dilutions of antibody […] Show less (-) |
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TG1004 |
The Tdp1 Assay Kit contains all reagents for routine detection of Tdp1 activity using the tyrosine release assay from the substrate Oligo-Tyr (human tdp1 is sold separately). The assay is highly specific for Tdp1. Summary: The kit contains reagents and protocols for assaying Tyrosyl DNA Phosphodiesterase (Tdp1). A procedure… Show more (+) The Tdp1 Assay Kit contains all reagents for routine detection of Tdp1 activity using the tyrosine release assay from the substrate Oligo-Tyr (human tdp1 is sold separately). The assay is highly specific for Tdp1. Summary: The kit contains reagents and protocols for assaying Tyrosyl DNA Phosphodiesterase (Tdp1). A procedure for making suitable cell extracts is described […] Show less (-) |
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TG2038 |
Tyrosyl-DNA phosphodiesterase-2 (TDP2) functions to remove trapped topoisomerase II/DNA complexes by processing 5′- blocking protein (topo II) at the site of the DNA break (Fig 1). Assaying this activity can be difficult, requiring labeled oligos and isotopes or complicated detections that are hard to set up. In many… Show more (+) Tyrosyl-DNA phosphodiesterase-2 (TDP2) functions to remove trapped topoisomerase II/DNA complexes by processing 5′- blocking protein (topo II) at the site of the DNA break (Fig 1). Assaying this activity can be difficult, requiring labeled oligos and isotopes or complicated detections that are hard to set up. In many cases, these assays are largely derivative from […] Show less (-) |
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