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Topo Enzymes & DNA Gyrases

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TG2000G
Highly purified DNA Gyrase is offered as a holoenzyme (contains both A,B subunits). This is an excellent reagent for supercoiling plasmids in vitro or for novel drug screens.
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TG2000EC
E. coli Topo IV is a type II topoisomerase that is encoded by two genes parC and parE in E. coli.  It is essential for decatenation and chromosomal segregation in E. coli; thus, topo IV tends to prefer intermolecular strand passing (catenating and decatenating reactions) over relaxation reactions.  It is…
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E. coli Topo IV is a type II topoisomerase that is encoded by two genes parC and parE in E. coli.  It is essential for decatenation and chromosomal segregation in E. coli; thus, topo IV tends to prefer intermolecular strand passing (catenating and decatenating reactions) over relaxation reactions.  It is overexpressed and purified for use.
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TG2005HRC
High purity, catalytically active Top1 Enzyme overexpressed in the baculovirus system and purified to single band homogeneity.  These preparations are cheaper than native topo I made from human tissue and offer excellent purity and high specific activity.
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TG2000H
Purified Human Topoisomerase IIα (Top2a) overexpressed and purified to homogeneity to a single band on SDS-PAGE.  Topoisomerase II is highly purified and free of topo I contamination.
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TG2005H-Y723F
Catalytically inactive form of mutant human topoisomerase I purified to homogeneity (single band on SDS-PAGE).  The mutation is a single residue change at the active site tyrosine (which has been changed to phenylalanine).  This preparation is overexpressed in baculovirus and affinity purified as a single band on SDS-PAGE…
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Catalytically inactive form of mutant human topoisomerase I purified to homogeneity (single band on SDS-PAGE).  The mutation is a single residue change at the active site tyrosine (which has been changed to phenylalanine).  This preparation is overexpressed in baculovirus and affinity purified as a single band on SDS-PAGE of 100 kDa.  The enzyme cannot relax DNA (but still binds to DNA) and contains a short (6 residue) histidine tag.
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$435.00
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TG2000GSA
Highly purified S. aureus DNA gyrase is a type II topoisomerase encoded by two genes GyrA and GyrB from staphylococcus aureus.  DNA gyrase is an essential topoisomerase that supercoils DNA through a process of strand breakage/resealing and DNA wrapping.  As a type II enzyme, gyrase is unique in…
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Highly purified S. aureus DNA gyrase is a type II topoisomerase encoded by two genes GyrA and GyrB from staphylococcus aureus.  DNA gyrase is an essential topoisomerase that supercoils DNA through a process of strand breakage/resealing and DNA wrapping.  As a type II enzyme, gyrase is unique in its ability to negatively supercoil a relaxed […]
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