Research Pipeline

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This page represents an overview of our research and development efforts.  If you are interested in discussing further information on any of the following projects please contact Mark (mark@topogen.com).

Bladder Cancer Diagnostics (BladCan™)
  • Diagnostic Kit for detection of Bladder Cancer in Patients
  • Non-invasive detection using urine sediments
  • IHC based detection
  • SBIR Phase I pending (L. Lignitt, PI)

I.P. Position: provisional filed, non-provisional conversion July 2011

Immune Tolerance in Multiple Sclerosis
  • Collaborative project on T-regulatory cell function in Multiple Sclerosis
  • NIH funding (in preparation); PI, Dr. V. De Rosa

I.P. Position: Pending (USPTO Provisional)

New Diagnostics for Autoimmune Diseases (Scleroderma)
  • Joint venture, Prius, SRA (Italy)
  • SBIR Phase I pending (Dr. G. Moroncini, PI)

I.P. Position: multiple patents filed (US and PCT)

New Diagnostics for Multiple Sclerosis
  • Joint venture, Prius, SRA (Italy)
  • NIH funding in preparation (Dr. G. Moroncini, PI)

I.P. Position: multiple patents filed (US and PCT)

 

Immune Tolerance in Multiple Sclerosis
  • Collaborative project on T-regulatory cell function in Multiple Sclerosis
  • NIH funding in preparation (Dr. V. de Rosa, PI)

I.P. Position: pending (USPTO provisional patent)

Anti-Cancer Therapeutics with Novel Gold Compounds
  • Innovative anti-topoisomerase I and II targeting drugs based on synthetic structures containing gold
  • Targeted toxicity combining poisoning and catalytic inhibition of DNA topoisomerase pathways
  • Initial screening done by National Cancer Institute demonstrated efficacy in cancer
  • Subsequent confirmation by TopoGEN showing topoisomerase targeting
  • NIH funding (SBIR Phase I) pending

I.P. Position: multiple patends filed in US and internationally

Anti-cancer Therapeutic Detection In Vivo (In Vivo Link Kit™)
  • Developed to clearly demonstrate Topoisomerase I and II poisoning in the context of the cell
  • Allows unambiguous demonstration of drug efficacy within tumor cells
  • DR-GFP Repair–we have engineered a HR repair reporter using GFP inside cells that contain an ultra-high affinity site for Topoisomerase II cleavages
  • Quantitative GFP readout allows in vivo screenign for topo active and DNA damaging agents

Operational Status: ongoing CRO activity in the mainstream company facility
I.P. Status: “soft IP” uses proprietary content to protect and cover all IP
SBIR Phase I Grant 2010-2011

Custom Drug Screening: Contract Research Organization (CRO)
  • Customized Screening Solutions for Novel Anti-cancer Drugs
  • Specific targets include:
    • Eukaryotic Topoisomerases (Type I, II, III)
    • Prokaryotic Topoisomerases (Gyrase, Topoisomerase IV) in E. Coli and S. Aureus
    • DNA Methyltransferase targets

Operational Status: ongoing, income streaming revenues for company operations
I.P. Position: provisional patent (USPTO) on Solid Phase Screening Systems

Research Diagnostics: Kits and Reagents for Research
  • Antibodies
  • DNA Targets
  • Kits
  • Enzymes
  • High throughput screening Solid Phase Systems (patent pending licensed from Univ. Central Florida)
  • In Vivo Screening for anticancer drug action (SBIR Phase I submitted/pending)

Operational Status: ongoing, income streaming revenues for company operation
I.P. Position: provisional patent (USPTO) on Solid Phase Screening Systems