A newly published study in Scientific Reports describes the identification and characterization of alternariol monomethyl ether (AME), a fungal secondary metabolite isolated from Alternaria alternata, with potent antiproliferative activity linked to inhibition of both DNA Topoisomerase I and II. Importantly, the investigators utilized TopoGEN’s plasmid relaxation and kDNA decatenation assay systems to quantify enzyme inhibition kinetics and demonstrate […]