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Topo Enzymes

Human Topo I
Mutant Human Topo I
Human Topo IIa
E. coli Topo IV

DNA Gryases

E. Coli DNA Gyrase
S. Aureus DNA Gyrase

Topo kits

Topo I Assay Kits
Topo II Assay KIts
Gyrase Assay Kit
DNA Unwiding Kit
Gyrase and Relaxed DNA Assay Kits
TopI-NucEx Kit
TopII-NucEx Kit
ICE Assay Kit

DNA Substrates

kDNA
Linear kDNA
Decatenated kDNA
Supercoiled pHOT-1
Relaxed pHOT-1

Drug Screening Kits

Topo I
Topo II
Topo II (kDNA based)
Topo IV
Gyrase
TopI Hi-Loading Inhibition Kit

TPD1 Products

TDP-1 Assay Kit
Human TDP-1
Polyclonal Antibody to Human TDP-1

TPD2 Products

Human TDP-2 Assay Kit
Human TDP2
TDP2 Substrate

Topo Related Drugs

Topotecan Hydrochloride (Hycamtin)
Camptothecin
9-Nitro-20 (S) Camptothecin (Rubitecan)
10-Hydroxy Camptothecin
9-Amino Camptothecin

Doxorubicin (Adriacin)
Daunomycin
Etoposide (VP16)
Amsacrine (m-AMSA)
Genistein
Ellipticine
HU-331

Gyrase & Topo Iv

Ciprofloxacin

Topo Antibodies

Topo I Antibodies

Polyclonal to Human Topoisomerase I (serum)
Monoclonal Antibody to Human Topoisomerase I
Polyclonal Antibody to Human Topoiosomerase I (Scleroderma Patient Serum)

Topo II Antibodies

Topoisomerase II Alpha C-Terminal Peptide
Polyclonal Antibody to Human Topoisomerase II Alpha
Monoclonal Antibody to Human Topoisomerase II Alpha
Polyclonal Antibody to Human Topoiosomerase II Beta
Polyclonal Antibody to Yeast Topoisomerase II (Serum)
Monoclonal Antibody to Human Topoiosomerase II Beta

Topo III Antibodies

Polyclonal Antibody to Human Topoisomerase III Beta
Monoclonal Antibody to Human Topoisomerase III Alpha

Topoisomerase II Immunoflourescence Kit
Topoisomerase II Immunoprecipitation Kit
Topoisomerase II Band Shift Kit

Protein Mw Markers

Human Topoisomerase II Alpha Molecular Weight Marker
Topoisomerase I Western Blot Marker

Cell Context DNA Repair

Homologous Recombination Reporter Cells

Human: HeLa Reporter Cell Line (Includes I-Sce1 Transfection)
Human: HeLa HR Reporter Cell line (Includes CRISPR-CAS Transfection)
Human: Neuroblastoma HR Reporter Cell line (SH-SY5Y, Includes I-Sce1 Transfection)
Mouse: 3T3 HR Reporter Cell Line (Includes I-Sce1 Transfection)
Mouse: Neuronal Lineage HR Reporter Cell line (Includes I-Sce1 Transfection)
Custom Cell Based Screening Kit for (HR) Pathway

Non-Homologous End Joining Reporter Cells

Human:HeLa NHEJ Reporter Cell Line (Includes I-Sce1 Transfection)
Human:HNSH NHEJ Reporter Cell line (Includes I-Sce1 Transfection)
Mouse:3T3 Fibroblast NHEJ Reporter (Includes I-Sce1 Transfection)
Custom Cell Based Screening Kit for NHEJ

Mobile Transient Assay DNA Repair Systems

Homologous Recombination (HR) DNA Reporter

Topo Enzymes

DNA Gyrases

Topo Kits

Drug Screening Kits

Topo Antibodies

Protein Mw Marker & Antiobody Kits

DNA Substrates

TDP1 Products

TDP2 Products

Topo Related Drugs

Stable Cell Lines for DNA Repair Assays

Transfection-based DNA Repair Assays

Topo Enzymes

Topo Enzymes

Human Topo I
Mutant Human Topo I
Human Topo IIa
E. coli Topo IV

DNA Gyrases

DNA Gyrases

E. Coli DNA Gyrase Enzyme
S. Aureus DNA Gyrase Enzyme

Topo Kits

Topo Kits

Topo I Assay Kit
Topo II Assay Kit
Gyrase Assay Kit
DNA Unwinding Kit
Gyrase & Relaxed DNA Assay Kits
TopI-NuEx Kit
TopII-NucEx Kit

Drug Screening Kits

Drug Screening Kits

Topo I
Topo II
Topo II (kDNA based)
Topo IV
Gyrase
Topo I Hi-Loading Inhibition Kit

Topo Antibodies

Top1 AB

Rabbit Polyclonal to Human Topo I (Serum)
Mouse Monoclonal to Human Topo I
Human Polyclonal to Human Topo I (Serum)

Top 2 AB

Rabbit Polyclonal to C-terminal human Top2alpha
Rabbit Polyclonal to Human Topo II Alpha
Mouse Monoclonal to Human Topo II Alpha
Polyclonal to Human Topo II Beta
Mouse Monoclonal to Human Topo II Beta
Polyclonal to Yeast Topo II (Serum)

Top 3 AB

Rabbit Polyclonal to Human Topo III Beta (Serum)
Mouse Monoclonal to Human Topo III Alpha

Protein Mw Marker & Antiobody Kits

Protein MW Markers & Antibody Kits

Human Topoisomerase II Alpha Molecular Weight Marker
Topoisomerase I Western Blot Marker

Topoisomerase II Immunoflourescence Kit
Topoisomerase II Immunoprecipitation Kit
Topoisomerase II Band Shift Kit

DNA Substrates

Top2/Gyrase Substrates & Markers

Kinetoplast DNA (kDNA) (Catenated kDNA)
Linear kDNA Marker
Decatenated kDNA Marker

Top1 pHOT-1 DNA Substrates & Markers

Supercoiled pHOT-1 Plasmid DNA Substrate
Relaxed pHOT-1 Plasmid DNA Substrate

TDP1 Products

TDP1 Products

TDP-1 Assay Kit
Human TDP-1
Polyclonal Antibody to Human TDP-1

TDP2 Products

TDP2 Products

Human TDP-2 Assay Kit
Human TDP-2
TDP-2 Substrate

Topo Related Drugs

Topotecan Hydrochloride (Hycamtin)
Camptothecin
9-Nitro-20 (S) Camptothecin (Rubitecan)
10-Hydroxy Camptothecin
9-Amino Camptothecin

Doxorubicin (Adriacin)
Daunomycin
Etoposide (VP16)
Amsacrine (m-AMSA)
Genistein
Ellipticine
HU-331

Gyrasev & Topo IV

Ciprofloxacin

Stable Cell Lines for DNA Repair Assays

These HR/NHEJ kits are cell based, meaning they have the HR or NHEJ GFP reporters pre-installed. A single plasmid (I-Sce1) is transfected to activate repair. Please see this table for a summary and comparison/application of each kit.

Homologous GFP Repair Systems

HeLa Cell HR Kit (I-Sce1 Based)

DR-3000 HR-Hela-Sce

HeLa Cell HR Kit (CRISPR-CAS Based)

DR-3000 HR-Hela-CPR

Human Neuroblastoma Cell Line SH-SY5Y using (I-Sce1 transfection)

DR-3000-HRSH-SCE

Mouse 3T3 Cell Line using I-Sce1 transfection

DR-3000-HR3T3-Sce

Mouse Neuronal Cell Line using I-Sce1 transfection

DR-3000-HRCN1.4-Sce

Custom construction Kit to make your own HR Cell Reporter

DR-3000-Custom Sce

NHEJ GFP Reporter
Systems

HeLa Cell Based NHEJ

Kit using I-Sce1 plasmid

DR5001-HN-Hela-Sce

Human Neuroblastoma

Cell Line HNSH NHEJ

using I- Sce1 transfection

DR5000-HNSH-Sce

Mouse 3T3 Cell Line

using I- Sce1

transfection

DR-5000-HN3T3-Sce

Mouse Neuronal Cell

Line using I-Sce1 I-

transfection

DR-5000-HNCN1.4-Sce

Custom construction Kit

to make your own NHEJ

Cell Reporter

DR-5000-Custom-Sce

Transfection-based DNA Repair Assays

Transfection-based HR and NHEJ kits use transient transfections to make a pool of cells containing the DNA reporters to allow the investigator to interrogate the 2 major DNA repair pathways. The advantages are:

It uses GFP readout to measure the efficiency of repair.
There is zero background when repair is blocked or inhibited
The reporters for HR or NHEJ can be installed in virtually any cell line that can be transiently transfect
It is rapid and robust
It is ideal for drug screens to find novel inhibitors of HR/NHEJ
The kits are highly specific and can only report HR or NHEJ
Readout GFP can be done by FACS or Imaging
Entire pathway can be followed by live imaging in viable cells
Ideal to track repair kinetics at the single cell level

HR Kit: DR-3050

NHEJ Kit: DRT-5050

For videos and more information visit here

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Topo Antibodies Archives - TopoGEN

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“Polyclonal Antibody to Yeast Topoisomerase II (Serum)” has been added to your cart. View cart

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Polyclonal to Human Topoisomerase I (serum)
$355.00 Add to cart
Monoclonal Antibody to Human Topoisomerase I
$355.00 Add to cart
Polyclonal Antibody to Human Topoisomerase I (Scleroderma Patient Serum)
$355.00 Add to cart
Topoisomerase II Alpha C-Terminal Peptide
$375.00 Add to cart
Polyclonal Antibody to Human Topoisomerase II Alpha
$355.00 Add to cart
Monoclonal Antibody to Human Topoisomerase II Alpha
$355.00 Add to cart
Polyclonal Antibody to Human Topoiosomerase II Beta
$355.00 Add to cart
Polyclonal Antibody to Yeast Topoisomerase II (Serum)
$355.00 Add to cart

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Polyclonal Antibody to Yeast Topoisomerase II (Serum)

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